ma·late syn·thase

an enzyme catalyzing the reversible condensation of acetyl-CoA with glyoxylate and water to form l-malate and coenzyme A; an enzyme in the glyoxylate cycle.

Synonym(s): glyoxylate transacetylase, malate-condensing enzyme

Farlex Partner Medical Dictionary © Farlex 2012

malate synthase

An enzyme that catalyses the reaction:
acetyl-CoA + H2O + glyoxylate <—> (S)-malate + CoA.

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References in periodicals archive

Isocitrate lyase (EC 4.1.3.1) and malate synthase (EC 2.3.3.9) are the sole enzymes for this metabolic pathway.

Further, glyoxylate condenses with a second acetyl-CoA molecule in a reaction catalyzed by malate synthase, after the malate produced is oxidized to oxaloacetate and thus regenerating the intermediate (steps B-1 to B-5, Figure 1).

Metabolic modeling and comparative biochemistry in glyoxylate cycle/Modelagem metabolica e bioquimica comparativo no ciclo do glioxilato

Malate synthase, GLcB, initially was characterized as an important enzyme of the glyoxylate shunt involved in carbon assimilation as energy source to bacilli [6].

Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis.

Health care workers humoral immune response against GLcB, MPT51 and HSPX from Mycobacterium tuberculosis

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