in 2014 described a 65-year-old woman presenting with severe dyspnea, facial edema, and
macroglossia without urticaria or pruritus [8].
GS is a condition of metabolism classified as a lysosomal storage disease associated with soft tissue aberrations; some of these present in the orofacial complex, for instance,
macroglossia and adenoidal/tonsillar hypertrophy.
We also noted generalized weakness associated with axial hypotonia and
macroglossia. Deep tendon reflexes were abolished.
His mouth tended to be open and he had macrostomia and
macroglossia with a grooved tongue and prognathism.
[sup][4] We also confirmed that
macroglossia resulting in dysarthria may occur in the patients with hereditary TTR amyloidosis, though that is more common in patients with light-chain amyloidosis.
It was common to observe facial immaturity manifested by
macroglossia (Figures 1(d) and 1(d1)), hypodeveloped eyelids, and nonperforated nostrils (Figures 1(a1), 1(c1), and 1(d1)).
There were no signs of prognatism or
macroglossia. Enlargement of the hands and feet and clubbing of the fingers were noted (Figure 2).
Other common signs and characteristics are excessive daytime sleepiness, insomnia or nighttime awakenings, obesity, snoring, gasping while sleeping,
macroglossia (enlarged tongue), retrognathia (recession of the chin), and tonsillar hyperplasia (Gutierrez & Brady, 2013; Krug, 1999).
The patient had fevers (maximum temperature 39.5[degrees]C); tachycardia; oropharyngeal mucositis; glossitis;
macroglossia; a tongue ulcer; decreased tongue movements; trismus; peripheral edema; tenderness on palpation of the limbs; mild bilateral facial weakness; and upper and lower limb weakness, marked in the hands.
There was no
macroglossia or disturbance of tongue mobility.