A total of 138 (3.7%) had
macrocytosis, with 128 of these patients having charts that could be reviewed.
Categories of Mean Corpuscular Volume and Associated causes of Anaemia Category Mean Corpuscular Possible causes of Volume Anaemia Iron deficiency, Gastrointestinal Microcytosis < 81 fL with small bleeding, red blood cells Thalassaemia, Anaemia of chronic inflammation Iron deficiency, Gastrointestinal Normal Range 81-100 fL bleeding, Thalassaemia, Anaemia of chronic inflammation B12/ folate deficiency, >100 fL with large drug effect,
Macrocytosis red blood cells Alcohol abuse, Myelodysplasia, Liver or thyroid disease Peripheral Smear Examination
Neuropsychiatry disorders caused by cobalamin deficiency in the absence of anemia or
macrocytosis. N Engl J Med.
Savage et al., "Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or
macrocytosis," New England Journal of Medicine, vol.
demonstrated in a population-based study among older from Finland that the presence of
macrocytosis or macrocytic anemia did not increase the odds of having vitamin [B.sub.12] deficiency, which is consistent with the present results [34].
Common laboratory findings of vitamin B12 deficiency is
macrocytosis with or without anemia and hypersegmented neutrophils.
Megaloblastic anemia and other causes of
macrocytosis. Clin Med Res 2006; 4: 236-41.
Among these, a number of previous studies have reported that eiythrocyte
macrocytosis, which refers to a high level of MCV, was exhibited in the disorder (Wachtel and Pueschel, I99I; David et al., 1996; Kivivuori et al., 1996; Dixon et al., 2010; Tenenbaum et aL, 20II).
Increase in red cell diameter above normal is called
macrocytosis. Red cell sizes form a basis for morphologic or cytometric classification of anaemia [28].
Vegans are at a significant risk of vitamin [B.sub.12] deficiency (3) which can lead to
macrocytosis, anemia, and decreased energy.
(9,10) Red blood cell size can easily be determined through dark field microscopy, with small cells (microcytosis) indicative of iron deficiency and large cells (
macrocytosis) of vitamin B12 or folate deficiency.