local anesthetic

An anesthetic drug that induces local anesthesia by inhibiting nerve excitation or conduction.

local anesthetic

Pain control An agent administered at the site of pain or anticipated pain–eg, before dental work or surgical incision Types Esters–hydrolyzed by pseudocholinesterase and amides–metabolized in the liver and excreted in urine; a vasoconstrictor, usually epinephrine, diluted to 1:200,000 may added to limit absorption, and enable use of more anesthetic. Cf General anesthesia.

Local anesthetic

Medication applied topically to the skin or administered through an injection that deadens a specific part of the body and inhibits the sensation of pain.

Mentioned in: Radial Keratotomy, Urinary Catheterization

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References in periodicals archive

Topical anesthetic application, such asEMLA (Eutectic mixture of local anesthetics:lidocaine 2.5%-prilocaine 2.5%) creamapplied 60 to 120 minutes prior to intralesionalanesthetic injection has been found in multiple studies to attenuate injection pain.17 Similarly,LET solution (lidocaine, epinephrine, tetracaine) application 30 minutes before wound/laceration closure,prior to actual lidocaine infiltration has been found to decrease the pain.18The disadvantage with these techniques is the extra time required for EMLA or LET to show the effect.

Minimizing the pain in local anesthesia injection - A review

Clinicians are urged to embrace the expanded role of Intralipid emulsion rescue therapy not only for local anesthetic drug toxicities, but also for other lipophilic drug overdoses.

Intralipid emulsion rescue therapy: emerging therapeutic indications in medical practice

This increases the elimination rate of local anesthetics resulting in a shorter duration of the axillary block compared to those with normal and mask the effects of tramadol.12

COMPARISON OF EFFICACY OF ROPIVACINE ALONE WITH TRAMADOL - ROPIVACAINE COMBINATION IN SUPRACLAVICULAR BRACHIAL PLEXUS BLOCK FOR UPPER LIMB SURGERY

A prospective randomized trial of different supplementary local anesthetic techniques after failure of inferior alveolar nerve block in patients with irreversible pulpitis in mandibular teeth.

COMPARISON OF EFFECTIVENESS OF 4% ARTICAINE BUCCAL INFILTRATION VERSUS INFERIOR ALVEOLAR NERVE BLOCK IN SYMPTOMATIC MANDIBULAR 1ST MOLAR TOOTH

(2011) The effect of local anesthetic and corticosteroid combinations on chondrocyte viability.

Reduction of environmental temperature mitigates local anesthetic cytotoxicity in bovine articular chondrocytes

Patients' pain scores during the application of local anesthetic were recorded.

A Needle-Free Injection System (INJEXTM) with lidocaine for epidural needle insertion: A randomized controlled trial

The most notable finding, however, is that among these adult medical-surgical patients, the majority who had any kind of experience with lidocaine as a local anesthetic for IV insertions would prefer to have it used in the future.

Using lidocaine for peripheral IV insertions: patients' preferences and pain experiences. (CE Series)

A wide range of compounds can function as local anesthetics, making description of the receptor difficult.

SOLVENT-ACCESSIBLE SURFACE AREA AS A PREDICTOR OF LOCAL ANESTHETIC ACTIVITY

Multi-regional local anesthetic infiltration during laparoscopic cholecystectomy in patients receiving prophylactic multi-modal analgesia: A randomized, double-blinded, placebo-controlled study.

INTRAPERITONEAL AND LOCAL INFILTRATION OF BUPIVACAINE FOR PAIN RELIEF AFTER LAPAROSCOPIC CHOLECYSTECTOMY

HTX-011 is the first and only long-acting local anesthetic to demonstrate in Phase 3 studies significantly reduced pain and opioid use compared to bupivacaine solution, the current standard-of-care local anesthetic for postoperative pain control, through 72 hours.

Heron: HTX-011 achieved all primary, key secondary endpoints in trial