leu·ko·cy·to·clas·tic vas·cu·li·tis

cutaneous acute vasculitis characterized clinically by palpable purpura, especially of the legs, and histologically by exudation of the neutrophils and sometimes fibrin around dermal venules, with nuclear dust and extravasation of red cells; may be limited to the skin or involve other tissues as in Henoch-Schönlein purpura.
See also: cutaneous vasculitis.

[G. leukos, white, + kytos, cell, + klastos, broken, fr. klao, to break]

Farlex Partner Medical Dictionary © Farlex 2012

allergic vasculitis

A form of nonthrombocytopenic purpura due to a hypersensitivity vasculitis associated with urticaria, erythema, arthritis, gastrointestinal symptoms and renal involvement.

leukocytoclastic vasculitis

Cutaneous necrotizing vasculitis A form of vasculitis with fragmentation of neutrophil nuclei, immune complex deposition–direct immunofluorescence demonstrates IgG, IgM and complement deposition, that elicits neutrophilic 'suicide' and deposition of abundant nuclear 'dust', necrotic debris and fibrin, most common in small post-capillary venules; the condition may be local–eg, cutaneous or systemic. See Vasculitis.

leu·ko·cy·to·clas·tic vas·cu·li·tis

(lū'kō-sī-tō-klas'tik vas'kyū-lī'tis)

Cutaneous acute vasculitis characterized clinically by palpable purpura, especially of the legs, and histologically by exudation of the neutrophils and sometimes fibrin around dermal venules, with nuclear dust and extravasation of red blood cells; may be limited to the skin or involve other tissues as in Henoch-Schönlein purpura.
See also: cutaneous vasculitis

[G. leukos, white, + kytos, cell, + klastos, broken, fr. klao, to break]

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

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References in periodicals archive

However, the skin biopsy revealed leukocytoclastic vasculitis and negative staining for Congo red and [kappa]-light chain, without IgA deposition.

Henoch-Schonlein purpura nephritis associated with monoclonal gammopathy of renal significance: a case report

We report the case of a 30-year-old man with visceral leishmaniasis (kala-azar) and leukocytoclastic vasculitis. The patient improved symptomatically following treatment with amphotericin B.

Rare Association of Leukocytoclastic Vasculitis in Visceral Leishmaniaisis

In conclusion, our patient presented with a clinical picture of leukocytoclastic vasculitis and necrotizing pneumonia, and a diagnosis of hydatid cyst disease of the lung was made.

Pulmonary hydatid cyst disease mimicking necrotizing pneumonia in a child with leukocytoclastic vasculitis

Leukocytoclastic vasculitis with perivascular localization and polymorphonuclear leukocytes' accumulation in the dermis was detected in the biopsy specimen taken from the active lesion (Figure 1c).

Truncal Erythema Elevatum Diutinum With Elevated Cryoglobulin Level

HSP, also known as anaphylactoid purpura and immunoglobulin A (IgA) vasculitis, is a small-vessel leukocytoclastic vasculitis characterized by the perivascular deposition of IgAl-based immune complexes in the walls of arterioles and postcapillary venules.

Henoch-Schonlein purpura

reported hypergammaglobulinemia in 50% of pSS patients with cutaneous purpura not associated with cryoglobulinemia, and the main histologic diagnosis of cutaneous vasculitis was leukocytoclastic vasculitis.[4] Ramos-Casals et al .[16] also found that pSS patients with low C4 level had a higher incidence of cutaneous vasculitis.

Clinical Profile and Significance of Mucocutaneous Lesions of Primary Sjogren's Syndrome: A Large Cross-sectional Study with 874 Patients

Microscopic evaluation reveals leukocytoclastic vasculitis. Perinuclear ANCA is more often positive than c-ANCA.

Bruises on the ears and body: could this patient's worsening bruises be explained by her history of drug use?

The differential diagnosis for venous stasis dermatitis includes cellulitis (which rarely presents bilaterally), deep vein thrombosis, asteatotic dermatitis, erysipelas (more superficial cellulitis that results in elevated, shiny plaques), pyomyositis, necrotizing fasciitis, leukocytoclastic vasculitis, and allergic contact dermatitis.

Bilateral cellulitis on legs? Think venous stasis dermatitis

Histological findings of papillary dermal edema, karyorrhexis, and the presence of neutrophils within the inflammatory infiltrate without evidence of leukocytoclastic vasculitis supported Sweet's Syndrome.

Atypical Histiocyte-Rich Sweet's Syndrome

Leukocytoclastic vasculitis and polyarteritis nodosa are most frequently associated with MDS [12].

A Rare Case of Paraneoplastic Aortitis Associated with Chronic Myelomonocytic Leukemia

Biopsy of the rash from his calf was positive for leukocytoclastic vasculitis. Autoimmune workup was negative except for elevated C-reactive protein (CRP).

Bilateral Testicular Infarction from IgA Vasculitis of the Spermatic Cords