A probe was inserted into the lacrimal sac from the lacrimal punctum to determine the precise location of the lacrimal sac.
In the control group, the epiphora was invisible, hyperemia was not found in the conjunctiva, no mucus or purulent discharge had outflowed from the lacrimal punctum, and the lacrimal passage was unobstructed (Figure 2(a)), which meant that animals in the control group did not show evidence of chronic dacryocystitis.
Meanwhile, although the rabbit only has one lacrimal punctum and canaliculus, the lengths and structures of its lacrimal sac and nasolacrimal duct that locates at the posterior part are similar to those found in human physiology, and its lacrimal duct histology is also similar to the human lacrimal duct in some respects.
At the end of the procedure, the polymerized adhesive could be seen over the lacrimal punctum and any remaining adhesive on the ocular surface was removed with the aid of a sterile swab or Adson forceps.
One animal from the GB group was presented with severe inflammatory reaction characterized by conjuctival hyperemia, chemosis, episcleral congestion and severe mucous discharge on the first day after the occlusion of the lacrimal punctum. Another animal from the same group developed severe pruritus two days after occlusion.