When patients were on a calcineurin inhibitor, the risk of
keratinocyte carcinomas increased incrementally by 2.6 events per 100 patients per year of follow-up, and the SCC risk increased by 1.7 events per 100 patients per year of follow-up.
To this end, a bi-channel device has been used to culture the
keratinocyte cell line HaCaT, as a model of the epidermis barrier, on one side, and a human leukemic monocyte lymphoma cell line (U937), to represent human dendritic cells, on the other side (Ramadan and Ting, 2016).
During wound healing process, dermis fibroblasts are responsible for synthesis and deposition of extracellular matrix collagen (Karimi et al., 2013; Dobosz et al., 2014)
Keratinocytes strongly contribute to the modulation of dermal fibroblast collagen production and degradation.
Microrna-31 promotes skin wound healing by enhancing
keratinocyte proliferation and migration.
STAT3 small interfering RNA carried by Lipofectamine 3000 combined with ultrasonic irradiation and SonoVue microbubbles inhibited the growth of psoriatic
keratinocytesAbbreviations CCL: C-C motif chemokine ligand CXCL: C-X-C motif chemokine ligand CX3CL: C-X3-C motif chemokine ligand G-CSF: Granulocyte-colony stimulating factor GM-CSF: Granulocyte-macrophage colony-stimulating factor IFN: Interferon IL: Interleukin K: Keratin KC:
Keratinocyte MMP-9: Matrix metalloproteinase-9 TGFa: Transforming growth factor alpha TNF[alpha]: Tumor necrosis factor alpha TNF[beta] Tumor necrosis factor beta VEGF: Vascular endothelial growth factor.
Recent studies demonstrated that EGF stimulates
keratinocyte division in vitro and epidermal regeneration in vivo [117].
Regulation of
Keratinocyte terminal differentiation by integrin extracellular matrix interactions.
The Inhibitory Effects of Wnt-CM on
Keratinocyte Migration Are Mediated by c-Myc.