We hypothesized that increased brain APA activity would evoke a pressor response and drinking behavior via AT1 receptor stimulation, and a decrease in
kallidin and increase in bradykinin as a consequence of APA activity would increase B2 receptor contribution to the pressor response.
The most important endogenous kinins are bradykinins,
kallidin, and methionine-lysine-bradykinin.
Kallikrein is involved in the biochemical reaction in the kidneyto produce
kallidin, which pharmaceutically appears to have vasodilator and natriuretic properties in animals.
High molecular weight Polypeptides or chemical mediators that induces pain like bradykinin, kallikrein &
Kallidin are increased in the phase of inflammation.
hK1 exerts its biological activity mainly through the release of lysyl-bradykinin (
kallidin) from low-molecular-weight kininogen.
Lewis, "Kinins in inflammation and tissue injury," in Bradykinin,
Kallidin and Kallikrein, pp.