Wraith, "Regulation of adaptive immunity; the role of
interleukin-10," Frontiers in Immunology, vol.
Preeclampsia is associated with a reduced
interleukin-10 production from peripheral blood mononuclear cells.
Interleukin-10 (IL-10) has a complex and predominantly opposing roles in inflammation and plays a major role in suppressing immune and inflammatory responses (6).
Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein.
Polymorphic haplotypes of the
interleukin-10 5' flanking region determine variable
interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis.
Two inhibitors of pro-inflammatory cytokine release,
interleukin-10 and interleukin-4, have contrasting effects on release of soluble p75 tumor necrosis factor receptor by cultured monocytes.
Interleukin-10 is widely known as an immunosuppressive cytokine by virtue of its ability to inhibit macrophage-dependent antigen presentation, T-cell proliferation, and Th1 cytokine secretion (6).
The immunological status of PKDL patients continues to be characterized but the picture is complex with mixed T cell responses and elevated levels of
interleukin-10 (IL-10) and tumour necrosis factor alpha (TNF-[alpha]) (6-9).
The results from a recent open-label study of 10 patients with mild to moderate Crohn's disease showed that treatment for 3 weeks with 15 g/day of a 30% inulin/70% oligofructose combination supplement was associated with improved disease activity and increased expression of the anti-inflammatory
interleukin-10, which is expressed in dendritic cells (Gut 2006;55:348-55).
"But studies have already shown that vitamin D can lower inflammation by increasing levels of anti-inflammatory messengers like the cytokine named IL-10 (
interleukin-10).
Specific proinflammatory cytokines (e.g.,
interleukin-10) and gender differences are also treated.