IL10

A gene on chromosome 1q31-q32 that encodes interleukin-10, a cytokine produced primarily by monocytes, but also by lymphocytes, which inhibits the synthesis of a number of cytokines (including IFN-gamma, IL-2, IL-3, TNF and GM-CSF) produced by activated macrophages and helper T cells. IL10 has pleiotropic effects in immunoregulation and inflammation. It downregulates expression of Th1 cytokines, MHC class-II antigens and co-stimulatory molecules on macrophages, and it enhances B cell survival, proliferation and antibody production. It can block NF-kappa B activity, and is involved in regulating the JAK-STAT signalling pathway.

Molecular pathology
IL10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

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References in periodicals archive

o Adiponectin, Cortisol, C-Peptide, E1G, FSH, HCGb, IL-6, IL-10

Multiplex ELISAs Offer Powerful Profiling Capabilities

IL-8 (D0) correlated with SOFA (D0) (rho = 0.27; p = 0.007), SOFA (D1) (rho = 0.36; p < 0.001), and SOFA (D3) (rho = 0.34; p = 0.001); IL-10 correlated with SOFA (D0) (rho = 0.3; p = 0.01), SOFA (D1) (rho = 0.4; p = 0.001), and SOFA D3 (rho = 0.26; p = 0.045); G-CSF (D0) correlated with SOFA (D1) (rho = 0.25; p = 0.01) and SOFA (D3) (rho = 0.24; p = 0.02); IL-17 (D0) correlated with SOFA (D0) (rho = 0.23; p = 0.01), but there was no correlation with SOFA (D1) or SOFA (D3).

T helper type cytokines in sepsis: time-shared variance and correlation with organ dysfunction and hospital mortality

Levels of IL-4, IL-6, IL-10 and IL-13 in mice serum were determined by sandwich-enzyme-linked immuno sorbent assay (ELISA) (Schumacher et al., 1988).

ANTI-INFLAMMATORY ROLE OF PEPTIDES ISOLATED FROM VENOM OF ANDROCTONUS FINITIMUS (POCOCK, 1897) (SCORPIONES: BUTHIDAE)

Liu further added, "What we found here is IL-10 promotes colon cancer."

Here's the relation between colitis and colon cancer

Interleukin-4 (IL-4), IL-5, and IL-10 are the main cytokines secreted by Th2 lymphocytes and eosinophils.

Changes and correlations of serum interleukins, adhesion molecules and soluble E-selectin in children with allergic rhinitis and asthma

Oxidative stress is often enhanced in patients with TIN, which promotes the expressions of inflammatory cytokines, such as IL-6, IL-10, and TNF-[alpha] (29).

Baicalein alleviates tubular-interstitial nephritis in vivo and in vitro by down-regulating NF-[kappa]B and MAPK pathways

In addition, it led to increased production of IFN-y and IL-17, and the decrease of IL-10 and TGF-[beta] in T CD[4.sup.+].

The role of regulatory T cells and anti-inflammatory cytokines in psoriasis

The expression of cytokines IL-23, IL-21, TNF-[alpha], and IL-10 did not have a significant association with the severity of chronic gastritis in this study (Figure 2, Table 2).

Proinflammatory Cytokine IL-17 Shows a Significant Association with Helicobacter pylori Infection and Disease Severity

Plasma levels of IL-6, IL-10, IL-8, and soluble TNF-a receptors at rest and after WBV are shown in Figure 1.

Acute Effects of Whole-Body Vibration on Inflammatory Markers in People with Chronic Obstructive Pulmonary Disease: A Pilot Study

During the follow-up, all clinical malaria episodes were recorded and respective blood samples were collected for determination of IL-10 and IFN-[gamma].

Interferon-[gamma] and Interleukin-10 Responses during Clinical Malaria Episodes in Infants Aged 0-2 Years Prenatally Exposed to Plasmodium falciparum: Tanzanian Birth Cohort

In order to determine the effect of inflammatory reactions in the pathogenesis of miscarriage, genotyping of promoter sites was carried out using the following polymorphic markers: G753A for TLR2; C399T for TLR4; G2848A for TLR9; C509T for TGF-[beta]1; PROGINS for PGR; G174C for IL-6; C781Tfor IL-8; C592A for IL-10; and G308A for TNF[alpha].

Effects of Single-Nucleotide Polymorphisms in Cytokine, Toll-Like Receptor, and Progesterone Receptor Genes on Risk of Miscarriage