tolerance

[tol´er-ans]

1. the ability to bear something potentially difficult.

2. the ability to endure unusually large doses of a poison or toxin.

3. drug tolerance. adj., adj tol´erant.

acquired drug tolerance drug tolerance.

ambiguity tolerance the ability to withstand conflicting or complex situations without undue psychological stress.

drug tolerance a decreasing response to repeated constant doses of a drug or the need for increasing doses to maintain a constant response. See also drug dependence and habituation.

immunologic tolerance specific nonreactivity of lymphoid tissues to a particular antigen capable under other conditions of inducing immunity.

standing tolerance the amount of time an individual is capable of maintaining an erect, upright position.

tolerance test

1. an exercise test to determine the efficiency of the circulation.

2. a test to determine the body's ability to metabolize a substance or to endure administration of a drug.

im·mu·no·log·ic tol·er·ance

lack of immune response to antigen. Theories of tolerance induction include clonal deletion and clonal anergy. In clonal deletion, the actual clone of cells is eliminated whereas in clonal anergy the cells are present but nonfunctional.

Synonym(s): immunotolerance, nonresponder tolerance

Farlex Partner Medical Dictionary © Farlex 2012

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References in periodicals archive

The activation of nTregs that occurs during EAT tolerance induction requires signaling through CTLA-4 for optimal tolerance development, indicating the importance of proper co stimulatory signals for nTreg activation, and underscoring the importance of the context of tolerogenic antigen for the induction of immunologic tolerance. Understanding the particular requirements for activation of nTregs and the subsequent induction of immunologic tolerance, rather than activation of autoreactive T cells and autoimmunity, is critical for rational development of new immunotherapies.

Role of suppressor T cells in various diseases

Roncarolo, "In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance," Blood, vol.

Liver transplant tolerance and its application to the clinic: can we exploit the high dose effect?

The greater prevalence of food allergy in children reflects both the increased predisposition of children to develop food allergies and the development of immunologic tolerance to certain foods over time.

Food allergy: an overview. (Mini-Monograph)

Tilney, "Immunologic tolerance to renal allografts after bone marrow transplants from the same donors," Annals of Internal Medicine, vol.

Heart allograft tolerance induced and maintained by vascularized hind-limb transplant in rats

Because immunologic tolerance is incomplete, it is not unexpected that IgG antibodies specific for food proteins are found in normal subjects with no signs or symptoms of food allergy (Barnes 1995; Barnes et al.

Assessment of the inherent allergenic potential of proteins in mice. (Mini-Monograph)