Of 414 patients in a managed care cohort who received long-term PPIs, only 8 had mild
hypomagnesemia (1.21.5 mg/dL) on nearly 14% of their combined 289 measurements.
The main reason for
hypomagnesemia in SBS is primarily malabsorption due to various factors previously described (18, 24).
Therefore, and after ruling out another possible etiology for PRES, we suspected
hypomagnesemia. This was confirmed in the chemical analysis that disclosed a particularly low magnesium level of 0.4 mg/ dl (range: 1.7-2.55 mg/dl).
Agus, "
Hypomagnesemia," Journal of the American Society of Nephrology, vol.
Several studies have shown that
hypomagnesemia is a common electrolyte derangement in clinical setting especially in patients admitted to intensive care unit (ICU) where it was found to be associated with increased mortality and hospital stay [23-25] (Table 4).
Hypomagnesemia Induced by Long-Term Treatment with Proton-Pump Inhibitors.
Prevalence of
hypomagnesemia and its predictive prognostic value in critically 111 medical patients.
Development of CPPD crystal deposition disease in young people (<55 years) may be associated with metabolic diseases such as hemochromatosis, hyperparathyroidism,
hypomagnesemia, Wilson's disease, hypothyroidism, gout, acromegaly, and X-linked hypophosphatemic rickets.
The paper begins with an observation of how often potassium and magnesium deficiencies are found concurrently: "Patients with congestive heart failure ...frequently show hyponatremia, hypokalemia, and
hypomagnesemia."
CNIs also lead to tubular functional alterations and ion homeostasis disturbances like hyperkalemia,
hypomagnesemia and magnesium wasting, distal tubular acidosis, and hyperuricemia.