Role of
homeobox genes in the patterning, specification, and differentiation of ectodermal appendages in mammals.
A dominant mutation in the maize
homeobox gene, Knotted-1, causes its ectopic expression in leaf cells with altered fates.
(39.) Lints TJ, Parsons LM, Hartley L, Lyons I, Harvey RR Nkx-2.5: a novel murine
homeobox gene expressed in early heart progenitor cells and their myogenic descendants.
Retinoic acid likely acts in this capacity by binding to receptors that regulate the expression of
homeobox genes.
Hake's finding, reported in a cover article of the international scientific journal Nature in 1991, added plants to the list of organism--fruit flies, beetles, worms, mice, frogs, and humans, for instance--already known to contain influential
homeobox regions.
A novel NK-type
homeobox gene, ENK (early embryo specific NK), preferentially expressed in embryonic stem cells.
En cuanto al gen
Homeobox Arx, se dice que tiene una accion indirecta en la diferenciacion de las celulas intersticiales, ya que tiene una expresion mas elevada en las celulas mioides.
Pit-Oct-Unc Domain, Class 1, Transcription Factor 1 (Pit1) is a member of the tissue-specic POU
homeobox transcription factor family that is found in all mammals.
The first article uses 7 challenging yet representative examples to comprehensively review some diagnostic strategies and algorithms; to update many recently described diagnostic markers, such as von Hippel-Lindau tumor suppressor gene protein (pVHL), paired box gene (PAX) 8, ETS-related gene (ERG), sal-like protein 4 (SALL4), sex-determining region Y box (SOX) 10, NK3
homeobox 1 (NKX3.1), discovered on GIST1 (DOG1), and Merkel cell polyomavirus (McPyV); and to refine the diagnostic IHC panels frequently used in daily practice.
The short stature
homeobox (SHOX) gene is located in the pseudo-autosomal regions of the short arms of the X and Y chromosomes.
The molecular genetic research showed the association between X-linked hearing loss and mutations in POU3F4 .[sup][3] This gene belongs to a superfamily of POU domain transcription factors (transcription factor 4 of the POU domain, Class III), which encodes transcription factor with bipartite DNA-binding domains, a 75-amino acid POU-specific domain that is linked by 17 amino acids to a 63-amino acid
homeobox domain.
To date, two major genes, forkhead box C1 (FOXC1) on chromosome 6p25 and pituitary
homeobox 2 (PITX2) on chromosome 4q25, have been demonstrated to cause ARS.