high-affinity hemoglobin

abnormal hemoglobins showing left-shifted oxygen dissociation curves and associated familial erythrocytosis. Forty-three high-affinity hemoglobins have been described, including, Hb Chesapeake, Hb J Capetown, Hb Malmo, Hb Yakima, Hb Kemp, Hb Ypsi (Ypsilanti), Hb Hiroshima, Hb Rainier, and Hb Bethesda.

Synonym(s): high-oxygen-affinity hemoglobin

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Mentioned in

oxygen-dissociation assay

References in periodicals archive

Many high-affinity hemoglobin variants have been identified, with mutations affecting numerous sites on the alpha or beta chain.

Investigation of our patient's erythrocytosis led to a diagnosis of Hb Sherwood Forest, a high-affinity hemoglobin that has been infrequently described in the medical literature.

described a young man with polycythemia who was found to be homozygous for the same high-affinity hemoglobin [6].

Heterozygous Hemoglobin Sherwood Forest Causing Polycythemia

Hemoglobin Great Lakes (beta 68 [E12] leucine replaced by histidine): a new high-affinity hemoglobin. Blood 1981;58:813-7.

A 14-year-old boy with chronic cyanosis, mild anemia, and limited physical resistance to stress

The possession of high-affinity hemoglobin by the juveniles would aid them in the acquisition of oxygen from this low-oxygen environment.

Functional and biochemical properties of the Hemoglobins of the burrowing brittle star Hemipholis elongata Say (Echinodermata, Ophiuroidea)

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