hereditary diffuse gastric cancer

An autosomal dominant cancer predisposition syndrome (OMIM:137215) with increased susceptibility to diffuse cancer, which begins in the stomach and typically spreads locally to the oesophagus, small intestine and other organs, as well as to adjacent lymph nodes.

Molecular pathology
CDH1 mutation causes hereditary diffuse gastric cancer.

Mentioned in

References in periodicals archive

A short guide to hereditary diffuse gastric cancer. Hered Cancer Clin Pract.

Cancer gastrico: punto de vista

Host factors that may confer higher risk for the development of cancer include mutation of the E-cadherin gene (as in the diffuse type), (11) genetic associations with certain ABO blood groups, male gender, and familial cancer syndromes such as hereditary diffuse gastric cancer (HDGC), familial adenomatous polyposis (FAP), Peutz-Jeghers syndrome, and hereditary non-polyposis colorectal cancer (HNPCC), but consideration of these entities is beyond the scope of this discussion.

A 29-year old woman presenting with abdominal pain and vomiting. (Clinical Case of the Month)

The rare syndrome, known as Hereditary Diffuse Gastric Cancer Syndrome, also increases their risk of getting colon cancer, and, for Ms.

`A story of hope'; Family has stomachs removed to fight cancer

Eleven of these families were affected by a type of disease called hereditary diffuse gastric cancer (HDGC).

Stomach cancer discovery; HEALTH

All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.