u·vo·mo·ru·lin

(yū'vō-mō'rū-lin),

A transmembrane protein that links plasma membranes of adjacent cells together in a Ca²⁺-dependent manner; aids in maintaining the rigidity of the cell layer.

Synonym(s): E-cadherin

[L. uva, bunch of grapes, + Mod. L. morula, dim. of L. morum, fr. G. moron, mulberry, + -in]

Farlex Partner Medical Dictionary © Farlex 2012

CDH1

A gene on chromosome 16q22.1 that encodes a calcium-dependent cell–cell adhesion glycoprotein (cadherin), which is involved in regulating cell–cell adhesions, mobility and proliferation of epithelial cells.

Molecular pathology
CDH1 loss-of-function mutations correlate with gastric, breast, colorectal, thyroid and ovarian cancer, and they are thought to contribute to cancer progression by increasing proliferation, invasion and/or metastasis. CDH1 mutation causes hereditary diffuse gastric cancer and an increased susceptibility to endometrial and ovarian cancers.

Mentioned in

References in periodicals archive

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

BmARM-Like Protein from Silkworm, Bombyx mori (Lepidoptera) is Putatively Involved in Response against BmNPV Infection

Uvomorulin: a nonintegral membrane protein of early mouse embryo.

Transicion epitelio-mesenquimatica (TEM): principios e impacto clinico en la terapia contra el cancer

The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex.

Expression of cell adhesion molecules in the normal and T3 blocked development of the tadpole's kidney of Bufo arenarum (Amphibian, Anuran, Bufonidae)/ Expressao das moleculas de adesao celular no desenvolvimento normal e com a inibicao do hormonio tireoidea do rim nas larvas do Bufo arenarum (Amphibia, Anura, Bufonidae)

At compaction a glycoprotein called "uvomorulin," which was being synthesized since the two-cell stage, and which had hitherto been evenly distributed on the cells' membranes, migrates to those areas on the membrane that are in contact with adjacent blastomeres.

Quaestio Disputata: delayed hominization, reflections on some recent Catholic claims for delayed hominization

Alterations in the expression of uvomorulin and Na+, and K+ adenosine triphosphate during mouse skin tumor progression.

Expression of E-cadherin and p53 proteins in human soft tissue sarcomas

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