They named the condition with medical jargon: clonal
hematopoiesis of indeterminate potential, or CHIP.
It is interesting to note here the role of microbial metabolites on
hematopoiesis. Josefsdottir et al.
In vitro, BMSCs were shown to support long-term
hematopoiesis [9].
Ghrelin produced this effect by enhancing migration of lymphoid precursors from the bone marrow by activating GHS-R-specific pathway19, suggesting role of ghrelin in stimulation of
hematopoiesis.
Some miRNAs were chosen because of their reported roles in
hematopoiesis mechanisms (table 1).
Additionally, lymphocytes produce IL-6, a cytokine that plays an important role in
hematopoiesis stimulation to promote hematological recovery [17].
Based on our previous report on transcription factor Gfil and cell surface marker CD48 in murine myeloid
hematopoiesis [23], we evaluated CD48 as a marker to effectively distinguish granulocytic MDSCs from monocytic MDSCs in septic mice.
Head and neck examination revealed depressed cranial vault, frontal bossing, retracted upper lip, and saddle nose (severe face deformity due to extramedullary
hematopoiesis).
Extramedullary
hematopoiesis (EMH) occasionally occurs in patients exhibiting hematological disorders with decreased hematopoietic efficacy, such as myelofibrosis, thalassemia, and polycythemia vera.
The company added that myelodysplastic syndromes are a complex and heterogeneous group of bone marrow failure disorders characterised by ineffective
hematopoiesis and poor prognosis.
The analytical units (XN-10) provide a comprehensive CBC and differential along with advanced measures of
hematopoiesis through advanced, reportable parameters: automated IG, NRBC (with every CBC), reticulocyte hemoglobin RET-He and immature reticulocyte fraction (IRF), immature platelet fraction (IPF) and fluorescent platelet count (PLT-F) and automated body fluid count (with a 2-part differential).
Despite a growing consensus that the AHR is an important regulator of
hematopoiesis (Boitano et al.