Coppola et al., "Identification of the
hemangioblast in postnatal life," Blood, vol.
Research by Professor Simon's group demonstrated that EBs with a disrupted HIF1 complex exhibited inappropriate mesodermal and
hemangioblast differentiation [5].
Xia et al., "Hemangioblastomas share protein expression with embryonal
hemangioblast progenitor cell," Cancer Research, vol.
During development, blood and vascular cells are thought to originate from a progenitor cell known as a
hemangioblast. This research project identified and imposed six transcription factors on the cells that al lowed
hemangioblasts to keep proliferating over multiple generations.
Vereide ct al.; "An Expandable, Inducible
Hemangioblast State Regulated by Fibroblast Growth Factor"; Stem Cell Reports, 2014; DOI: 10.1016/j.
Peng, "Increased
hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice," Development, vol.
patent for its method of generating and expanding
hemangioblast cells from human embryonic stem cells.
Brachyury or T is a member of T-box (TBX) gene family and encodes a transcription factor required in posterior mesoderm formation and axial development along with the development of the
hemangioblast. Initially it appears in the marginal zone of the blastocyst and subsequently restricts its expression into the notochord and the tail bud.
Preclinical data demonstrating
hemangioblast potential of marrow cells and cardioprotective effects of growth factors served as the basis for numerous early phase clinical trials.
Keller, "Development of the
hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures," Blood, vol.
The new method may overcome these limitations because of a versatile precursor cell called the "
hemangioblast."