Symptoms increase with age due to the progressive
glycolipid accumulation in the vascular system, kidneys and heart leading to kidney failure, heart disease or strokes.
Glycolipid (cerebroside and ganglioside), particularly cerebroside, has been proved to exhibit various physiological activities, including antitumor/cytotoxic (Natori et al., 1994; Jin et al., 1994; Li et al., 1995; Chen et al., 2009), antifungal (Jin et al., 1994), immunomodulatory, cyclooxygenase inhibitory, and antifouling activities (Mansoor et al., 2007).
IgM anti-phenolic
glycolipid I and IgG anti 10-kDp a heat shock protein antibody in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts.
Brennan, "A novel phenolic
glycolipid from Mycobacterium leprae possibly involved in immunogenicity and pathogenicity," Journal of Bacteriology, vol.
The levels of blood glucose, blood triglyceride, and cholesterol significantly decreased following TSF treatment; these beneficial effects can be achieved via TSF regulating action on the
glycolipid metabolism.
Natural killer T cells recognize
glycolipid antigens presented by CD1d molecule and may also play an important role in oral tolerance by inducing tolerogenic dendritic cells and regulatory T cells, or by deleting antigen-specific T cells.
Sialic acids widely distributed in nature as terminal sugars in glycoproteins or
glycolipids, impart a net negative charge to cell surface and are reported to be important in cell-to-cell and cell-to-matrix interactions.
Phenolic
glycolipid (PGL)-I is one of the major components of the cell wall of M.
In this regard, we have identified
glycolipid accumulation and, specifically, lyso-Gb3 accumulation as a driver of uPAR expression in podocytes (Figure 2).