A4GALT

Alpha 1,4-Galactosyltransferase. A gene on chromosome 22q13.2 which encodes alpha-1,4-galactosylstransferase, an enzyme that transfers a galactose to lactosylceramide, forming globotriaosylceramide, a glycolipid also known as P(k), of the P blood group system, formally known as CD77.

References in periodicals archive

Using serum from an SLE patient who showed hemolytic anemia, SARF revealed that cDNA inserted into the cloned cells that were sorted with this AECA-IgG was alpha 1,4-galactosyltransferase (A4GALT).

Identification of A4GALT indicated the usefulness of SARF, which can be used to identify genes that encode not only the membrane protein itself, but also the transferase(s) responsible for modifying the membrane protein.

Olsson, "Identification of a novel A4GALT exon reveals the genetic basis of the P1/P2 histo-blood groups," Blood, vol.

An innovative method to identify autoantigens expressed on the endothelial cell surface: serological identification system for autoantigens using a retroviral vector and flow cytometry (SARF)

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