Ristocetin aggregation will be abnormal in Bernard Souvelier Syndrome (
Giant Platelet Syndrome).
Platelet-rich plasma is an artificial milieu deficient in
giant platelet subspecies as well as erythrocytes and leukocytes, which are regarded as critical modulators of platelet function in vivo (15).
Inherited
giant platelet disorders: classification and literature review.
However, platelet-rich plasma is an artificial milieu deficient in
giant platelet subspecies as well as erythrocytes and leukocytes, which are regarded as critical modulators of platelet function in vivo (12).
(28)
Giant platelet disorders also have characteristic electron microscopic findings.
Few disclaimers have to be considered while one interprets MPV in isolation: a spurious increase in MPV contributed by red blood cell fragmentation which can be counted by the analyzer as a
giant platelet, a combination of hypoproductive and hyperdestructive thrombocytopenia and splenic sequestration; where large platelets are entrapped in spleen but not released into the circulation.
Increased bleeding after surgery or trauma may be difficult to control.7 BSS patients shows an increased bleeding time, decreased platelets count to near normal and presence of
giant platelets on peripheral smear.
Automated haematology analysers produce erroneous results in the presence of particles of similar size and shape and in the presence of
giant platelets and platelet clumps.
His platelet count was 3,321,000/[micro]L (reference range: 140,000-400,000/[micro]L) and was described as
giant platelets on peripheral smear.
Giant platelets were found in his peripheral blood smear and bone marrow aspiration showed elevated megakaryocytes with no evidence of hemophagocytosis.