Inherited
platelet disorders including Glanzmann thrombasthenia and Bernard-Soulier syndrome.
Myeloid Neoplasms With Germline Predisposition and Preexisting
Platelet DisordersPlatelet transfusions can be life-saving for patients dealing with cancer or the effects of chemotherapy, infections, immune disorders, or
platelet disorders.
They also serve children with other factor deficiencies such as von Willebrand disease, Glanzmann Thrombasthenia, and functional
platelet disorders.
The laboratory diagnosis of
platelet disorders: an algorithmic approach.
Platelet disorders are another group of bleeding disorders, in which bleeding can result from a decrease in platelet count (thrombocytopenia), with a reported incidence of 1.9 and 6.4 per 10 children/year.
Payrastre, "Inherited
platelet disorders and oral health," Journal of Oral Pathology & Medicine, vol.
Platelet disorders can be classified according to disorders of platelet function.
Outside of von Willebrand in such patients, possible
platelet disorders could include Glanzmann thrombasthenia (a platelet function disorder that is caused by an abnormality in the genes for glycoproteins IIb/IIIa) and platelet storage pool disorder, both of which should be diagnosed by a hematologist.
Suspected cases of
platelet disorders should be referred to a hematologist even if initial hematologic assessments, including blood counts and PT/PTT, appear normal.
Platelets play a cardinal role in haemostasis.1 Platelets are transfused in order to prevent or treat bleeding in various clinical conditions.2 Platelet transfusion improves the management of patients with haemostatic or
platelet disorders, reducing haemorrhagic complications and mortality.3 Prophylactic and supportive use of platelet transfusion has significantly increased in the last few decades.
Patients were excluded if they had history of cardiac surgery, pregnancy,
platelet disorders, haematological malignancy, recent chemotherapy, splenectomy, ICU stay of <48 hours, were <18 years of age or had a history of readmission to the ICU during the same hospital stay.