ne·o·na·tal hep·a·ti·tis

hepatitis in the neonatal period presumed to be due to any of a variety of causes, chiefly viral; characterized by direct and indirect bilirubinemia, hepatocellular degeneration, and appearance of multinucleated giant cells; may be difficult to distinguish from biliary atresia, but is more likely to end with recovery, although cirrhosis may develop.

Synonym(s): giant cell hepatitis

Farlex Partner Medical Dictionary © Farlex 2012

A nonspecific reaction of the newborn liver to increased conjugated hyperbilirubinemia, which occurs with intra- or extrahepatic biliary atresia, erythroblastosis fetalis, TORCH (toxoplasmosis, rubella, cytomegalovirus, herpes simplex) and other in utero and neonatal infections (e.g., coxsackie, hepatitis, Escherichia coli infection, syphilis) and metabolic defects (e.g., a1-antitrypsin deficiency; cystic fibrosis; hereditary fructose intolerance; galactosemia; tyrosinosis requiring parenteral nutrition; choledocal cysts, idiopathic, congenital hepatic fibrosis, trisomy 18 and Byler’s, Lucey-Driscoll, Niemann-Pick and Zellweger’s diseases)

giant cell hepatitis

Giant cell transformation of liver Neonatology A nonspecific reaction of the newborn liver to ↑ conjugated hyperbilirubinemia; conjugated BR is ↑ in infants with intra- or extrahepatic biliary atresia, erythroblastosis fetalis, TORCH–toxoplasmosis, rubella, CMV, HS, and other in utero and neonatal infections–eg, coxsackie, hepatitis, E coli, syphilis, metabolic defects–eg, α₁-antitrypsin deficiency, cystic fibrosis, hereditary fructose intolerance, galactosemia, parenteral nutrition and tyrosinosis, choledocal cysts, idiopathic, congenital hepatic fibrosis, Byler's disease, Lucy-Driscoll disease, Niemann-Pick disease, trisomy 18, and Zellweger's disease. Cf Syncytial giant cell hepatitis.

Mentioned in

References in periodicals archive

Syncytial giant cell hepatitis (GCH) is a condition characterized by inflammation and multinucleated hepatocytes, commonly found in wide spectrum of neonatal and infantile liver diseases [1].

Westerhoff et al., "Neonatal giant cell hepatitis: Histological and etiological findings," The American Journal of Surgical Pathology, vol.

Postinfantile Giant Cell Hepatitis with Features of Acute Severe Autoimmune Hepatitis Probably Triggered by Diclofenac in a Patient with Primary Myelofibrosis

Giant cell hepatitis with autoimmune hemolytic anemia in children: Proposal for therapeutic approach.

FREQUENCY OF CAUSES OF CHRONIC LIVER DISEASE IN CHILDREN

[sup][3] Liver biopsy often shows giant cell hepatitis, and at late stages, bridging fibrosis and micronodular cirrhosis can also be seen.

Novel Mutations in the 3[beta]-hydroxy-∆5-C27-steroid Dehydrogenase Gene (HSD3B7) in a Patient with Neonatal Cholestasis

A wide spectrum of primary liver diseases in systemic lupus erythematosus have been demonstrated by various authors and include viral hepatitis, autoimmune hepatitis, primary biliary cirrhosis, granulomatous hepatitis, giant cell hepatitis, chronic hepatitis with IgA or IgD deficiency, porphyria or idiopathic portal hypertension, and rarely lymphoma.

McMahon, "Giant cell hepatitis associated with systemic lupus erythematosus," Journal of Clinical Pathology, vol.

Spectrum of histomorphologic findings in liver in patients with SLE: a review

Giant cell hepatitis associated with direct Coombs' test-positive hemolytic anemia is a rare condition of childhood and the pathogenesis remains unclear.

Key words: Giant cell hepatitis, immune hemolytic anemia, direct Coombs' test, rituximab

Autoimmune hemolytic anemia and giant cell hepatitis: report of three infants / Otoimmun hemolitik anemi ve dev hucreli hepatit birlikteligi olan uc olgunun sunumu

Liver histology showed, among other features, a giant cell hepatitis which has not yet been described for drug-induced liver disease (Zimmerman, 1999).

Suspected hepatotoxicity by Cimicifugae racemosae rhizoma (black cohosh, root): critical analysis and structured causality assessment

Then doctors discovered Rachel had giant cell hepatitis, a rare but still treatable type of hepatitis.

Family People: Our baby got his life for Christmas; After developing hepatitis at birth, doctors said Charlie Tobey would be dead within days. But then he received the best Christmas present ever - his life. SUSANNA GALTON reports..

This leaves a large group of infants with what is called IDIOPATHIC NEONATAL HEPATITIS, Giant Cell Hepatitis or familial Cholestatis.

Neonatal hepatitis

Giant cell hepatitis, however, is usually caused by various degrees of insults to the immature liver, or can be idiopathic.

Neonatal giant cell hepatitis: a case study