A whitish cord made up of myelinated or unmyelinated nerve fibres held together by connective tissue sheath in bundles and through which stimuli are transmitted from the central nervous system to the periphery or vice versa.
abducens nerve Sixth cranial nerve. It has its origin from the abducens nucleus at the lower border of the pons and at the lateral part of the pyramid of the medulla. It passes through the cavernous sinus and enters the orbit through the superior orbital fissure. It supplies motor innervation to the ipsilateral lateral rectus muscle. Additionally, interneurons leave the abducens nucleus and project to the contralateral medial rectus sub nucleus to allow conjugate gaze. A lesion in the nuclear region will cause gaze palsy, whereas an abducens nerve lesion will produce only an abduction deficit.
See abducens nucleus;
paralysis of the sixth nerve.
cranial nerve's Twelve pairs of nerves, one set on each side of the brain, that emerge, or enter the cranium. They carry sensory information from the sense organs, the muscles of the head, neck, shoulders, heart, viscera and vocal tract. The motor neurons with axons in the cranial nerves control pupil diameter, accommodation, movements of the eyes and eyelids, mastication, facial expression, head movements, as well as cardiorespiratory and digestive functions.
nerve fibre layer See retina.
fifth cranial nerve See trigeminal nerve.
fourth cranial nerve See trochlear nerve.
frontal nerve See ophthalmic nerve.
nerve impulse See action potential.
infratrochlear nerve See ophthalmic nerve.
lacrimal nerve See ophthalmic nerve.
long ciliary nerve One of a pair of nerves that comes off the nasociliary nerve and runs with the short ciliaries, pierces the sclera, travels in the suprachoroidal space and supplies sensory fibres to the iris, cornea, and ciliary muscle and sympathetic motor fibres to the dilator pupillae muscle (Fig. N2).
See ophthalmic nerve;
pupil light reflex.
nasociliary nerve See ophthalmic nerve.
oculomotor nerve Third cranial nerve. It is classified as a motor nerve. Its origin lies in the tegmentum of the midbrain. It passes through the cavernous sinus and just before it enters the orbit it divides into a small superior and a larger inferior division. Both divisions penetrate into the orbit through the superior orbital fissure. In the orbit the superior division passes inward above the optic nerve to supply the superior rectus and the levator palpebrae superioris muscles. The inferior division sends branches to the medial rectus, the inferior rectus and inferior oblique muscles, as well as providing parasympathetic fibres to the sphincter pupillae and ciliary muscles via a branch to the ciliary ganglion.
See oculomotor nucleus;
paralysis of the third nerve.
ophthalmic nerve This is the smallest of the three divisions of the trigeminal nerve, the other two being the maxillary and mandibular branches. It comes off the medial and upper part of the convex anterior border of the gasserian ganglion (trigeminal ganglion), passes through the cavernous sinus and just behind the superior orbital fissure it divides into three branches, the
lacrimal,
frontal and
nasociliary, which pass through the fissure to enter the orbit. (1) The smallest of the three, the
lacrimal nerve, supplies sensory fibres to the lacrimal gland, the skin of the upper eyelid and the conjunctiva. Just before reaching the gland the nerve communicates with the zygomaticotemporal nerve (itself a branch of the zygomatic nerve). This branch contains parasympathetic fibres from the facial nerve that pass to the lacrimal gland. (2) The
frontal nerve, which is the largest of the three divisions, divides into the
supratrochlear and
supraorbital nerves. The supratrochlear further anastomoses with the
infratrochlear nerve and supplies the lower part of the forehead, the upper eyelid and the conjunctiva. The infratrochlear supplies sensory fibres to the skin and conjunctiva round the inner angle of the eye, the root of the nose, the lacrimal sac and canaliculi and caruncle. The supraorbital nerve sends sensory fibres to the forehead, the upper eyelid and conjunctiva. (3) The
nasociliary nerve gives origin to several nerves: the long ciliary nerves, the long or sensory root (ramus communicans) to the ciliary ganglion, the posterior ethmoidal nerve and the infratrochlear nerve (Fig. N2).
optic nerve Second cranial nerve. It forms a link in the visual pathway. It takes its origin at the retina and is made up of nearly 1.2 million fibres from the ganglion cells and some efferent fibres that end in the retina. The nerve runs backward from the eyeball and emerges from the orbit through the optic canal and then forms the optic chiasma. The total length of the optic nerve is 5 cm; the portion before the chiasma called intracranial being about 1 cm, the intracanalicular 6 mm, the intraorbital 3 cm and the intraocular 0.7 mm. The optic nerve is more often divided into only two portions: the
intraocular (
bulbar) portion and the
orbital (
retrobulbar) portion (Fig. N2).
See optic atrophy;
pupillary fibres;
optic neuritis;
anterior ischaemic optic neuropathy;
papilloedema.
short ciliary nerve One of six to ten branches from the ciliary ganglion that enters the eye around the optic nerve, travels in the suprachoroidal space and innervates the ciliary muscle, the sphincter pupillae muscle and the cornea.
See pupil light reflex.
sixth cranial nerve See abducens nerve.
supraorbital nerve; supratrochlear nerve See ophthalmic nerve.
third cranial nerve See oculomotor nerve.
trigeminal nerve Fifth cranial nerve. It is the largest of the cranial nerves. It originates above the middle of the lateral surface of the pons as two divisions, a larger sensory root and a motor root. The sensory root passes to the gasserian ganglion (trigeminal ganglion) and from that ganglion the three divisions of the fifth nerve are given off: the
ophthalmic,
maxillary and
mandibular nerves. The fifth nerve is sensory to the face, the eyeball, the conjunctiva, the eyebrow, the teeth, the mucous membranes in the mouth and nose. The motor root of the nerve has no connection with the ganglion. It joins the mandibular nerve and is motor to the muscles of mastication.
trochlear nerve Fourth cranial nerve. It is the most slender of the cranial nerves but with the longest intracranial course (75 mm). It is the only motor nerve that originates from the dorsal surface of the brain between the midbrain and the cerebellum. It passes through the cavernous sinus and then enters the orbit through the superior orbital fissure and supplies motor fibres to the superior oblique muscle.
See trochlear nucleus;
paralysis of the fourth nerve.
zygomatic nerve A branch of the maxillary division of the trigeminal nerve, it enters the orbit by the inferior orbital fissure and soon divides into the
zygomaticotemporal and
zygomaticofacial branches. The former gives a twig to the lacrimal nerve and is thought to conduct autonomic fibres to the lacrimal gland and the latter supplies the skin over the zygomatic bone.


Fig. N2 Diagram of the ophthalmic division of the trigeminal nerve (fifth). This is a view of the right eye from above (c.b.z, communicating branch to the zygomatic nerve)
Table N1 Cranial nerves |
nerve | | type | | function (sensory is in italic, the rest is motor) |
I | olfactory | | sensory | | smell |
II | optic | | sensory | | vision |
III | oculomotor | | mixed, primarily motor | | movement of eye and eyelids, regulation of pupil size, accommodation, proprioception |
IV | trochlear | | mixed, primarily motor | | eye movements, proprioception |
V | trigeminal | | mixed | | chewing movements, sensations from head and face, proprioception |
VI | abducens | | mixed, primarily motor | | abduction, proprioception |
VII | facial | | mixed | | facial expression, secretion of saliva and tears, taste, proprioception |
VIII | vestibulo-cochlear1. auditory (or cochlear) branch2. vestibular branch | | sensory | | hearingsense of balance |
IX | glossopharyngeal | | mixed | | secretion of saliva, taste, control of blood pressure and respiration, proprioception |
X | vagus | | mixed | | smooth muscle contraction and relaxation (e.g. heart) sensations from organs supplied, proprioception |
XI | accessory | | mixed, primarily motor | | movements of head, swallowing movements and voice production, proprioception |
XII | hypoglossal | | mixed, primarily motor | | tongue movements, proprioception |