Active pharmacologic management of the third stage of labour: A comparison of oxytocin and
ergometrine. Obstet Gynecol.
In the study 79% of women received either oxytocin,
ergometrine or both, as is routine in the NHS.
The drugs commonly used are oxyitocin,
ergometrine and misoprostol.
However, misoprostol is now gaining favor over dinoprostone for patients who fail both oxytocin and
ergometrine. Given at a dose of 1,000 [micro]g (five tablets) rectally, it was 100% effective in 14 such patients (Obstet.
(340) Although
ergometrine may cause bronchospasm particularly in association with general anaesthesia, (340) this is not a problem encountered when syntometrine (syntocinon/ergometrine) is used for postpartum haemorrhage prophylaxis.
Mrs Wildsmith was given
ergometrine - a drug routinely given to mothers to ensure the placenta comes away from the uterine wall.
Currently, the import of ergotamine,
ergometrine, pseudoephedrine, ephedrine, and lysergic acid is conditional with the recommendation from the Narcotics Division.
(47.) For data on RU 486/oral misoprostol abortion, see Thong & Baird, 1992 (4% of users: 1 woman needed emergency curettage for heavy bleeding due to incomplete abortion; 3 women were given intramuscular
ergometrine for heavy bleeding at the time of expulsion of products); Peyron, et al., 1993 (0.4% of patients (2 women) in study 1 had hemorrhage requiring hemostatic curettage, with one patient needing a blood transfusion 9 days after misoprostol when hemoglobin fell from 13.0 g/dl to 6.1 g/dl); McKinley, et al., 1993 (5.5% had a drop in hemoglobin >2 g/dl, but no blood transfusions).
In addition, given the increased risk and danger of haemorrhage in the context of CS, addition of
ergometrine for women without contraindications, and a second dose of oxytocin after 4 hours, have been recommended.
She continued to bleed on and off and after 10 minutes intravenous
ergometrine 0.5mg was given but the bleeding continued.
AbstractObjective: To compare the safety and efficacy of 10 units of intravenous syntocinon alone with 10 units intravenous syntocinon and 0.25mg intramuscular
ergometrine in the prevention of atonic uterine haemorrhage during caesarean section.Method: The quasi-experimental study was conducted at the Maternal and Child Health Centre Unit I Pakistan Institute of Medical Sciences Islamabad from November 1 2010 to February 28 2011.
Injection Oxytocin 20 IU and Inj Nexbolic (Methyl
ergometrine maleate) 3 ml was administered by l/M route on 1S1 day only.