Meyer et al., "Immunohistochemical analysis of thymidylate synthase, thymidine phosphorylase, and
dihydropyrimidine dehydrogenase in rectal cancer (cUICC II/III): correlation with histopathologic tumor regression after 5-fluorouracil-based long-term neoadjuvant chemoradiotherapy," The American Journal of Surgical Pathology, vol.
Impacts of excision repair cross-comple menting gene 1 (ERCC1),
dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer.
A role for
dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil.
Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil.
Quantitation of
dihydropyrimidine dehydrogenase expression in tumor specimens of patients treated with 5-fluorouracil using a quantitative polymerase chain reaction assay.
Colorectal tumors responding to 5-fluorouracil have low gene expression levels of
dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.
u1 addition, four patients with a disorder of the urea cycle and two patients with a
dihydropyrimidine dehydrogenase deficiency were investigated.
In this paper, Lassmann and colleagues have evaluated the predictive value of five molecular markers associated with the metabolism of fluoropyrimidines [thymidylate synthase (TS), thymidine phosphorylase (TP),
dihydropyrimidine dehydrogenase (DPD), uridine phosphorylase (UP) and uridine-cytidine kinase (UK)] and three molecular markers associated with cell proliferation and anti-apoptosis (Bcl-2-related protein, survivin and cyclin-D1).
Dihydropyrimidine dehydrogenase catalyzes the reduction of uracil and thymine to 5,6-dihydrouracil and 5,6-dihydrothymine, respectively.
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the three-step degradation of uracil to [beta]-alanine (12).