Migranal

A nasal spray formulation of an ergot compound used to manage migraines, but not hemiplegic or basilar migraines and not as prophylaxis.

Adverse effects
Rarely: cardiac events, including coronary artery vasospasm, transient myocardial ischaemia or infarction, ventricular tachycardia and ventricular fibrillation. More commonly: burning sensation, dysgeusia, diarrhoea, dizziness, drowsiness, dry mouth, hot flushes, irritation, nasal congestion or dryness, nasal discharge, nausea, sinusitis, sore throat, exhaustion, weakness.

Mentioned in

Migranal

References in periodicals archive

STS101 is a drug-device combination of a proprietary dry-powder formulation of dihydroergotamine mesylate (DHE), which can be quickly and easily self-administered with a proprietary pre-filled, single-use, nasal delivery device.

Satsuma Pharmaceuticals Announces First Patient Dosed in EMERGE, a Phase 3 Efficacy Trial of STS101 for the Acute Treatment of Migraine

It contains a reformulation of the drug dihydroergotamine mesylate (DHE) in a proprietary Tempo inhaler that allows DHE to be rapidly absorbed from the pleural mucosa into the systemic circulation.

"Levadex (Migraine) - Forecast and Market Analysis to 2023" Published

Zogenix, Incorporated's sales force has initiated promotion of Migranal(dihydroergotamine mesylate, USP) Nasal Spray in the United States under the company's exclusive co-promotion agreement with Valeant Pharmaceuticals North America LLC.

ZOGENIX BEGINS PROMOTION OF MIGRANAL NASAL SPRAY

Inpatients can be switched to intravenous DHE (dihydroergotamine mesylate) and outpatients can be given Migranal NS.

Overuse of headache drugs can be overcome

If headaches recur, treat attacks earlier, increase the dose, switch triptans, particularly to naratriptan or frovatriptan, add an NSAID, or switch to dihydroergotamine mesylate, Dr.

Get it right the first time with high-dose triptan: in patients with acute migraine, the greater chance of improvement offsets the risk of adverse events

Dihydroergotamine mesylate Paddock Laboratories D.H.E.

FDA first-time generics approvals--2003

by altering serotonin transmission through the use of serotonin receptor agonists (e.g., sumatriptan), lithium (e.g., lithium carbonate), tricyclic antidepressants (e.g., imipramine) or ergotamine alkaloids (e.g., dihydroergotamine mesylate, methysergide).

Nocturnal headaches--new theories, new treatments

The triptans and possibly dihydroergotamine mesylate (DHE-45) can be very helpful for certain types of tension-type headaches, especially in patients who also get migraines.

Exercise Cuts Tension Headache Frequency in Half