Migranal

A nasal spray formulation of an ergot compound used to manage migraines, but not hemiplegic or basilar migraines and not as prophylaxis.

Adverse effects
Rarely: cardiac events, including coronary artery vasospasm, transient myocardial ischaemia or infarction, ventricular tachycardia and ventricular fibrillation. More commonly: burning sensation, dysgeusia, diarrhoea, dizziness, drowsiness, dry mouth, hot flushes, irritation, nasal congestion or dryness, nasal discharge, nausea, sinusitis, sore throat, exhaustion, weakness.

Migranal®

Dihydroergotamine mesylate Neurology An antimigraine agent. See Migraine.

Patient discussion about Migranal

Q. what can cause a migrane other than light, noise, andno sleep? Well its been 4 days n 3 nights that I have it n it dont go away it was bad at first but then my right ear hurted as well as my right upper wisdomteeth It seems to be in only the right side and its been movin down towards my neck... Please if u have any info on wha the fuck is goin on with me let me know asap...

A. A migraine attack can be triggered also by caffeine consumption, alcohol consumption, certain medications, allergic reactions, physical or emotional stress, smoking, skipping meals, menstrual cycle fluctuations, menopause, and certain food containing-
1) tyramine- red wine, aged cheese, smoked fish, chicken liver, figs and some beans.
2) nitrates - like hot dogs, bacon and salami.

More discussions about Migranal

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Mentioned in

dihydroergotamine mesylate

References in periodicals archive

AUC0-2hr following administration of INP104 (1.45 mg), Migranal (2 mg), and D.H.E 45 (1 mg IV) was 1603, 387.5, and 3022 hrpg/mL, respectively, in the STOP 101 trial.

Impel NeuroPharma - Comparison of Early Plasma Exposure of DHE following Delivery by Nasal, Oral Inhalation, or Intravenous Administration

Unit dose devices are used to treat conditions such as migraine pain (Imitrex and Zomig), cancer pain (Instanyl), vitamin B12 deficiency (Nascobal), and heroin overdose (Narcan); multi-dose devices are for conditions such as allergy (Flonase, Nasacort), sinus congestion (Mucinex Sinus, Similisan Nasal Allergy Relief), cold relief (Zicam), migraine pain (Migranal), pain management (Sprix) and nocturia (Noctiva).

Nasal Drug Delivery: A look at best practices for testing nasal drug delivery devices

> Erenumab (Aimovig), Verapamil (Calan, Verelan), propranolol (Inderal LA, Innopran XL), metoprolol tartrate (Lopressor), amitriptyline, topiramate (Topamax), Botox, Sumatriptan (Imitrex), zolmitriptan (Zomig), dihydroergotamine (Migranal), ergotamine and caffeine (Migergot, Cafergot) for migraines

Type of Headache Determines the Best Treatment: Migraine, tension, and cluster headaches have different symptoms and causes

Hawley, chief executive officer of Zogenix, stated, "Since entering into our co-promotion agreement with Valeant at the end of June, we have worked closely with their team to rapidly train our sales force to promote Migranal, a number of whom previously promoted the product before joining Zogenix.

ZOGENIX BEGINS PROMOTION OF MIGRANAL NASAL SPRAY

Migranal is a dihydroergotamine available in formulations for subcutaneous injection and as a nasal spray.

Tough migraines may warrant combined Tx

Important precautions Azithromycin may interact with other antibiotics, and also with blood thinners such as warfarin (Coumadin); migraine medications such as dihydroergotamine (Migranal) and ergotamine (Ergomar, Cafergot); and increase levels of digoxin (Lanoxin), which is used to treat heart failure and atrial fibrillation.

Azithromycin

Medications that treat migraines: Anti inflammatories Aspirin (Bayer, Bufferin, Excedrin), ibuprofen (Motrin, Advil), naproxen (Aleve, Nuprin) Triptans Sumatriptan (Imitrex), rizatriptan (Maxalt), zolmitriptan (Zomig) Ergotamines DHE (dihydroergotamine) nasal spray (Migranal), DHE injection.

Over-the-counter medication may help ease migraine pain: a new study shows that acetaminophen may help treat migraine symptoms

45, Migranal Other Butalbital, acetaminophen, and caffeine Fioricet Leuprolide acetate Lupron, Eligard

The gynecologist's role in managing menstrual migraine: your expertise in manipulating the hormonal underpinnings of this pervasive complaint may be the missing link in treating it successfully

The ergot alkaloids include ergotamine titrate and dihydroergotamine (DHE 45, Migranal nasal spray), which cause constriction of peripheral and cranial blood vessels.

Pharmacological management for the adult migraine sufferer

Inpatients can be switched to intravenous DHE (dihy-droergotamine mesylate) and outpatients can be given Migranal NS.

Develop strategy to halt overuse of pain Meds

Launched in the spring, Sinol's nasal spray is designed to offer consumers an alternative to an array of prescription-strength nasal sprays, including GlaxoSmithKline PLC's Imitrex, AstraZeneca Pharmaceuticals LP's Zomig and Valeant Pharmaceuticals International's Migranal.

'Modern medicine does not hold all the answers'

In the first 6 months of 1997, the following new drugs were approved by the FDA: Agrylin, Alesse, Anzemet, Carbatrol, Fareston, Flomax, Galzin, Idamycin, Migranal, Posicor, Prelay, Prevacid, Pytest, Requip, Resulin, Serlect, Skelid, Tasmar, Uniretic, Urso, Vicoprofen, Viracept, Zyban.

Supporting pharmaceutical studies for FDA submissions: diversifying the drug monitoring laboratory