dif·fuse cu·ta·ne·ous leish·man·i·a·sis

leishmaniasis caused by several New and Old World species and strains of Leishmania (L. mexicana amazonensis, L. m. pifanoi, possibly L. m. garnhami and L. m. venezuelensis; in Ethiopia, L. aethiopica, and unidentified leishmanial agents in Namibia and Tanzania). The condition is associated with a suppressed cell-mediated immune response, so that the nonulcerating, nonnecrotizing cutaneous lesions can spread widely over the body; great numbers of parasite-filled macrophages are found in the dermal lesions. Healing does not seem to occur unless an acquired cellular hypersensitivity can develop.
See also: cutaneous leishmaniasis.

Synonym(s): anergic leishmaniasis, diffuse leishmaniasis, disseminated cutaneous leishmaniasis, leishmaniasis tegumentaria diffusa, pseudolepromatous leishmaniasis

Farlex Partner Medical Dictionary © Farlex 2012

dif·fuse cu·ta·ne·ous leish·man·i·a·sis

(di-fyūs' kyū-tā'nē-ŭs lēsh'mă-nī'ă-sis)

A disorder caused by several New and Old World species and strains of Leishmania. The condition is associated with a suppressed cell-mediated immune response.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

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References in periodicals archive

Monocyte suppression of antigen specific responses in diffuse cutaneous leishmaniasis patients Dominican republic.

Therapeutic and adverse effects of standard- dose and low-dose meglumine antimoniate during systemic treatment of Syrian cutaneous leishmaniasis patients

amazonensis have been isolated from a diffuse cutaneous leishmaniasis case in Bolivia [41].

chagasi in a case of diffuse cutaneous Leishmaniasis in Bolivia," Transactions of the Royal Society of Tropical Medicine & Hygiene, vol.

Concomitant infection with Leishmania donovani and L. major in single ulcers of cutaneous leishmaniasis patients from Sudan

Several Leishmania species are able to cause a wide spectrum of clinical manifestations of CL, ranging from the mild cutaneous form (localized cutaneous leishmaniasis, LCL) to multiple non ulcerative nodules (diffuse cutaneous leishmaniasis, DCL) and the disfiguring mucosal form (mucocutaneous leishmaniasis, MCL) [2].

The role of inflammatory, anti-inflammatory, and regulatory cytokines in patients infected with cutaneous Leishmaniasis in Amazonas State, Brazil

Diffuse cutaneous leishmaniasis (DCL) resembles leprosy and is difficult to treat.

Leishmaniasis in Pak-Afghan Region

Infections in humans may either be non-apparent or may display a clinical spectrum ranging from localized, sometimes self-healing cutaneous lesions, to severe mutilating mucocutaneous lesions, or diffuse cutaneous leishmaniasis (AKILOV et al., 2007).

Evaluation of HIV-Leishmania co-infection in patients from the northwestern Parana State, Brazil/Avaliacao da co-infeccao HIV-Leishmania em pacientes da regiao noroeste do Estado do Parana, Brasil

Treatment of diffuse cutaneous leishmaniasis with miltefosine: a case report.

MILTEFOSINE IN TREATMENT OF OLD WORLD CUTANEOUS LEISHMANIASIS IN PAKISTAN

Diffuse cutaneous leishmaniasis develops in the setting of infections with L.

Parasites and the skin: parasitic infections may be confined to the skin or may have skin involvement as part of their pathology

Polar and subpolar diffuse cutaneous leishmaniasis in Brazil: clinical and immunopathologic aspects.

Increased levels of IL-10, IL-12, and IFN-[gamma] in patients with visceral leishmaniasis

After promising results were obtained with miltefosine in a patient with anergic diffuse cutaneous leishmaniasis (ADCL) in Venezuela (2), the patient received 150 mg/day oral miltefosine (Impavido, Zentaris, Germany) for 98 days and the lesional parasite load was quantified with quantitative nucleic acid sequence-based amplification (3).

Leishmania (Leishmania) amazonenis: infection, Suriname