The RADAR study: week 48 safety and efficacy of RAltegravir combined with boosted
DARunavir compared to tenofovir/emtricitabine combined with boosted
darunavir in antiretroviral-naive patients.
Effect of
darunavir on lipid profile in HIV-infected patients.
Clinical improvement was seen within one week of treatment initiation with ART consisting of
darunavir, ritonavir, tenofovir, and emtricitabine.
The attending physician then switched antiretroviral regimen to stavudine/lamivudine/boosted
darunavir regimen.
Tremblay, "Combating HIV resistance--Focus on
darunavir," Therapeutics and Clinical Risk Management, vol.
(22) Co-formulation of
darunavir with cobicistat, tenofovir alafenamide, and emtricitabine is in phase III studies.
NEW YORK -- Janssen Pharmaceutical Cos., a unit of Johnson & Johnson, has extended its commitment to improve the health of children living with HIV through an expanded policy aimed at enhancing access to its HIV medicine
darunavir. J&J says that this policy enables the development of and access to new pediatric products of
darunavir in about 130 low- and middle-income countries that are home to 99.8% of children and adolescents living with HIV worldwide.
The company offers protease inhibitors such as ritonavir,
darunavir, saquinavir, amprenavir, lopinavir, atazanavir, indinavir and tipranavir.
He was switched to ritonavir,
darunavir, tenofovir disoproxil fumarate, and zidovudine and had successful virologic suppression to < 200 copies.
Standard guidelines recommend that initial treatment of patients with HIV-1 infection under HAART therapy should have a ritonavir- (RTV-) boosted protease inhibitor, usually
darunavir (DRV) or atazanavir (ATV) together with other antiretrovirals (ARVs) [3].
Interestingly, the same property is noted for
darunavir and atazanavir, but my clinical experience has found this less common with once-daily dosage.