cystathionine

[sis″tah-thi´o-nēn]

a thioester of homocysteine and serine; it serves as an intermediate in the transfer of a sulfur atom from methionine to cysteine.

cys·ta·thi·o·nine

(sis'tă-thī'ō-nēn),

The l-isomer is an intermediate in the conversion of l-methionine to l-cysteine; cleaved by cystathionases.

Farlex Partner Medical Dictionary © Farlex 2012

cys·ta·thi·o·nine

(sis'tă-thī'ō-nēn)

An intermediate in the conversion of l-methionine to l-cysteine; cleaved by cystathionases.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

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References in periodicals archive

Homocystinuria caused by cystathionine beta-synthase deficiency.

Trastornos psiquiatricos secundarios a enfermedades neurometabolicas

cruzi appears to be the first protist proven to have two independent pathways for cysteine production; sulfur-assimilation from sulfate and transsulfuration from methionine via cystathionine. Extracellular L-cysteine, but not L-cystine, has been shown to be essential for growth of the T.

Trypanosoma cruzi: analysis of two different strains after piplartine treatment

In vivo, five enzymes are associated with [H.sub.2]S synthesis: cystathionine [beta]-synthase (CBS), 3-mercaptopyruvate sulfurtransferase (3-MST), cystathionine [gamma]-lyase (CSE), cysteine aminotransferase (CAT), and Damino acid oxidase (DAAO) [30].

Roles of Gasotransmitters in Synaptic Plasticity and Neuropsychiatric Conditions

Hcy levels are regulated by vitamin [B.sub.12]- and folate-dependent remethylation to Met, catalyzed by Met synthase (with methyltetrahydrofolate cofactor provided by the MTHFR enzyme) and betaine-Hcy methyltransferase, as well as by vitamin B6-dependent transsulfuration to cysteine, the first step of which is catalyzed by cystathionine [beta]-synthase (CBS).

Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice

Homocysteine is a sulfur containing amino acid which is formed during the metabolism of methionine.8 The one half of Hcy is used in synthesis of cysteine via trans-sulfuration by vitamin B6 dependent enzyme, cystathionine beta synthase (CBS).

Correlation between Hyperhomocysteinemia and Common Carotid Artery Intima media Thickness in Carbamazepine treated Epileptic patients using Ultrasonography

The taurine, cysteine and cystathionine concentrations were determined with L-8900 automatic amino acid analyzer (Hitachi Ltd, Tokyo, Japan) after 0.22 [micro]m polyethylene membrane filtration.

Effects of different methionine sources on production and reproduction performance, egg quality and serum biochemical indices of broiler breeders

He has gained worldwide recognition for his research achievements on thymidylate synthase, cystathionine P-synthase (enzymes involved in folate, homocysteine metabolism), diagnostic imaging, HIV-1 envelope glycoproteinbased vaccines and enzyme-based targeted therapies for treating autoimmune diseases during his appointments at University of Iowa, GE Global Research, University of Michigan, Scripps--USA andUniversity of Queensland.

Investigating the pharmacological connection between methylene tetrahydrofolate reductase (MTHFR) enzyme deficiency and use of complementary medicine supplements such as activated B vitamins

The key stemness genes glutaminase 2 (GLS2), cystathionine-beta-synthase (CBS), and cystathionine gamma-lyase (CTH) were enriched in CTC-MCC-41, whereas CD200 molecule (CD200), spalt like transcription factor 4 (SALL4), and inhibitor of DNA binding 1 (ID1) were over-represented in HT-29.

Molecular Portrait of Metastasis-Competent Circulating Tumor Cells in Colon Cancer Reveals the Crucial Role of Genes Regulating Energy Metabolism and DNA Repair

You et al., "Dysregulation of cystathionine gamma-lyase (CSE)/hydrogen sulfide pathway contributes to ox-LDL-induced inflammation in macrophage," Cellular Signalling, vol.

Hydrogen Sulfide Inhibits High Glucose-Induced sFlt-1 Production via Decreasing ADAM17 Expression in 3T3-L1 Adipocytes