APL-2 is a synthetic
cyclic peptide conjugated to a polyethylene glycol (PEG) polymer that binds specifically to C3 and C3b, effectively blocking all three pathways of complement activation (classical, lectin, and alternative).
APL-9, an investigational drug, is a pegylated synthetic
cyclic peptide designed to modulate the complement cascade centrally at C3.
Cyclic peptide CP1: Fmoc-protecting group of Fmoc-Leu-NH-SAL-Trt(2-Cl)-resin (500 mg, 0.43 mmol) was deprotected by treatment with 20% piperidine in DMF.
The group identified a
cyclic peptide that could bind to hair under shampooing conditions, which meant a low pH and in the presence of surfactants.
Among poor sleepers, a higher proportion of patients tested positive for rheumatoid factor and anti-citrullinated
cyclic peptide (anti-CCP) autoantibodies.
0-Defensins are naturally expressed in Old World monkeys and are the only
cyclic peptide identified in mammals [107].
Tan, "Selection of high affinity ligands to hepatitis B core antigen from a phage-displayed
cyclic peptide library," Journal of Medical Virology, vol.
Although the cyclic NGR binds with higher affinity than linear NGR, and drug conjugates with the
cyclic peptide have 10-fold greater antitumor efficacy, the linear NGR has been the preferred ligand on the surface of nucleic acid carriers because it avoids cysteine bridges that may occur between different carrier molecules.
Figures 1 represent only results derived from the three methods for the detection of
cyclic peptide hepatotoxin genes by using HEPF and HEPR primers was developed to identify potentially microcystin or nodularin in two genus of cyanobacteria.
Facile synthesis of orthogonally protected amino acid building blocks for combinatorial N-backbone
cyclic peptide chemistry.