Most patients with dry eye benefit from topical treatment with 0.2%
cyclosporin A, especially when the STT values are higher than 2mm [min.sup.-1].
Microscale high-performance liquid chromatography-electrospray tandem mass spectrometry assay for
cyclosporin A in blood.
Simultaneous quantification of cyclosporin A and its major metabolites by time-of-flight secondary-ion mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry utilizing data analysis techniques: comparison with high-performance liquid chromatography.
Quantitative measurement of cyclosporin A in blood by time-of-flight mass spectrometry.
[3] Nonstandard abbreviafions: CSA, Cyclosporin A; MS, mass spectrometry; LC, liquid chromatography; MS/MS, tandem MS; CSD, Cyclosporin D; and CID, collision-induced dissociafion.
Clinical stability was defined as the absence of acute rejection, febrile infection, and cyclosporin A toxicity, as well as stability of creatinine clearance as estimated by the formula of Cockroft and Gault (27).
Equations of the linear regression lines between cystatin C reciprocals and CrCl estimates were as follows: 1/cystatin C = 0.3413 + [0.00685 X CrCl] (r = 0.65) in the cyclosporin A alone group; 1/cystatin C = 0.173 + [0.00850 X CrCl] (r = 0.76) in the cyclosporin A-azathioprine group; 1/cystatin C = 0.0860 + [0.00838 X CrCl] (r = 0.86) in the low-dose glucocorticoid group; and 1/cystatin C = 0.1318 + [0.00534 X CrCl] (r = 0.69) in the high-dose glucocorticoid group.
In comparison with the group receiving cyclosporin A alone, the group receiving low-dose glucocorticoids had cystatin C concentrations that differed by the following: 0.20 mg/L at 80 mL x [min.sup.-1] x 1.73 [m.sup.-2]; 0.27 mg/L at 70 mL x [min.sup.-1] x [1.73.sup.-2], by 0.37 mg/L at 60 mL x [min.sup.-1] x 1.73 [m.sup.-2]; by 0.52 mg/L at 50 mL x [min.sup.-1] x 1.73 [m.sup.-2]; by 0.75 mg/L at 40 mL x [min.sup.-1] x 1.73 [m.sup.-2]; by 1.13 mg/L at 30 mL x [min.sup.-1] x 1.73 [m.sup.-2]; and by 1.85 mg/L at 20 mL x [min.sup.-1] x 1.73 [m.sup.-2.].