coumarin

[koo´mah-rin]

1. a principle extracted from the tonka bean, from which several anticoagulants are derived that inhibit hepatic synthesis of vitamin K–dependent coagulation factors.

2. any of these derivatives.

cou·ma·rin

(kū'mă-rin),

1. A general descriptive term applied to anticoagulants and other drugs derived from dicumarol, a component of the Tonka bean.

2. A fragrant neutral principle obtained from the Tonka bean, Dypterix odorata, and made synthetically from salicylic aldehyde; it is used to disguise unpleasant odors.

Synonym(s): coumaric anhydride, cumarin

[coumarou, native name of Tonka bean]

Farlex Partner Medical Dictionary © Farlex 2012

coumarin

(ko͞o′mər-ĭn)

A fragrant crystalline compound, C₉H₆O₂, present in tonka beans and produced synthetically for use as a fragrance. Coumarin has been banned as a food additive in the United States because it can be toxic in large amounts.

cou′ma·ric (-mər-ĭk) adj.

cou·ma·rin

(kū'mă-rin)

Fragrant neutral principle obtained from the Tonka bean, Dypterix odorata, and also made synthetically from salicylic aldehyde; used to disguise unpleasant odors.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

cou·ma·rin

(kū'mă-rin)

A general descriptive term applied to anticoagulants and other drugs derived from dicumarol.

Medical Dictionary for the Dental Professions © Farlex 2012

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References in periodicals archive

Synthesis of Macromonomer and Comb Copolymer Synthesis of 7-Hydroxy-4-Chloromethyl Coumarin [CMHC]

Characterization and Synthesis of This Comb Type Copolymer with Styrene Using A Macromonomer Containing Polyethylmethacrylate

Flavonoids and coumarins of leaves of Heracleum antasiaticum Manden.

Flavonoid Glycosides from Heracleum pastinaca Fenzl/Heracleum pastinaca Fenzl'in Flavonoit Glikozitleri

For determining coumarin content, leaves were collected from the apical, middle, and basal segments.

Radiation levels of UV-A and UV-B on growth parameters and coumarin content in guaco/ Niveis de radiacao UVA e UVB sobre parametros de crescimento e conteudo de cumarina em guaco

The mechanism underlying this observation may be MK-7's much longer half-life time in the circulation and its reported 6-fold higher cofactor activity in vitro." However, before continuing, as will be reported shortly, the adverse impact of MK-7 on efficacy of coumarin anticoagulants is dose-dependent.

Thoughts at Large: Controversies in Clinical Nutrition and Functional Medicine Issue # 12 VITAMIN K1 VERSUS THE MK-7 VERSION OF VITAMIN K2 SUPPLEMENTATION: WHICH IS BEST FOR YOUR PATIENTS?

A) 7-Hydroxy-4', 6-dimethoxyisoflavone; B) chalepin; C) coumarin 2; D) coumarin 3; E) coumarin 4; F) guajaverin; G) coumarin 5; H) isosakuranetin; I) mangiferin; J)3', 4', 5', 5, 7-pentamethoxyflavone; K) quercetin; L) tiliroside.

In silico Study of the Antichagasic Activity of Aromatic Compounds

Investigation of polyphenolic profile of ethanol extracts of Lentinus squarrosulus and Termitomyces robustus showed the presence of phenolic acids, flavonoids and coumarin (Table 1) which have been proofed through researches to possess various antioxidant properties.

Bioactivity Studies on Two Wild Edible Mushrooms Extracts

The lifetime fluorescence measurements of the coumarin derivative and human serum albumin complex were detected using Fluorolog (Horiba Jobin Yvon IBH, UK) with a fast response sensitive PMT detector (Hamamatsu Photonics, Japan) for an excitation wavelength of 280 nm to 450 nm.

4-Hydroxycoumarin Derivative: N-(diphenylmethyl)-2-[(2-oxo-2H-chromen-4-yl)oxy]acetamide Interaction with Human Serum Albumin

The coumarin derivative (compound 2) was selected here because of its high emission efficiency, facile preparation procedure, excellent water solubility, and biocompatibility.

A Turn-On Fluorescent Probe for Sensitive Detection of Cysteine in a Fully Aqueous Environment and in Living Cells

Coumarin compounds as potential anticancer agents have become a rapidly developing, extremely active, and attractive topic.

Synthesis of Novel 1,2,4-Triazolyl Coumarin Derivatives as Potential Anticancer Agents

reported the synthesis of a series of compounds (32a-e) containing both coumarin and triazolothymidine (AZT-31, a well-known HIV-1 RT inhibitor) moieties to obtain dual action HIV-1 PR and RT inhibitions (Figure 11) [36].

Applications of Click Chemistry in the Development of HIV Protease Inhibitors

In conclusion, among the coumarin compounds that we successfully synthesized, compounds I c, I d, II c and II d had a strong electron-withdrawing group (-CH2Cl, -Cl, -CN and -CF3) in the phenyl ring with the highest cytotoxic activity against the cancer cell lines tested.

Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines