Erythrophagocytosis by undifferentiated lung carcinoma cells.
Autopsy revealed splenomegaly and
erythrophagocytosis with histiocytic hyperplasia in bone marrow, spleen, and lymph nodes, consistent with HLH.
A histological analysis of the aspirate revealed histiocytes associated with
erythrophagocytosis. Further, haemophagocytic histiocytes were observed with a decrease in erythropoietic and granulopoietic cells, while megakaryocytes were rarely observed (Figure).
Canonne-Hergaux, "Sequential regulation of ferroportin expression after
erythrophagocytosis in murine macrophages: Early mRNA induction by haem, followed by iron-dependent protein expression," Biochemical Journal, vol.
Kupffer cell
erythrophagocytosis and scarce sickle cells were still seen in a biopsy performed on the following day (Figure 2), along with some ischemic areas.
The histological lesions observed in the spleen included extramedullary hematopoiesis (63.3%),
erythrophagocytosis (57%), lymphoid hyperplasia (55%), central follicular necrosis (49%), lymphoid rarefaction (45%), hemosiderosis (37%), and inflammatory infiltrate of plasma cells (6%).
Histological lesions of pulmonary, hepatic and splenic
erythrophagocytosis and hemosiderosis were found in 23 of 24 birds.
Iron release from macrophages after
erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin.
[23] GUEGAN, F.; PLAZOLLES, N.; BALTZ, T; COUSTOU, V.,
Erythrophagocytosis of desialylated red blood cells is responsible for anaemia during Trypanosoma vivax infection.
Anemia might be due to haemolysis associated with decrease life span of RBCs and extensive
erythrophagocytosis (Nongo et al., 2015).
There were no tumor cells, pseudorosettes, storage cells, and/or
erythrophagocytosis in the bone marrow; thus an immune thrombocytopenia was considered (Figure 2).