Previous studies also showed that chemical sympathectomy with 6-OHDA can delay reepithelialization in cutaneous wounds [12, 14].
[14] demonstrated that chemical sympathectomy led to reduced MC migration during cutaneous wound healing in rats.
Roeske, "Effects of chemical sympathectomy with 6-hydroxydopamine on aand [beta]-adrenoceptors and muscarinic cholinoceptors in rat kidney," European Journal of Pharmacology, vol.
(2001) demonstrated that chemical sympathectomy with 6-OHDA improves survival in mice infected with Listeria monocytogenes, with augmented production of IFN-g, IL-1b, IL-2, IL-4 and IL-6; conversely, noradrenaline inhibited their secretion, but no change was observed in IL-4.
After 7 days of inoculation, rats developed yellowish abscesses with well-delimited borders (arrow) (a); reduction of abscesses size (arrow) was observed when trophozoites inoculated rats were treated with vehicle (b); however, chemical sympathectomy with 6-OHDA induces size diminution of the abscess (arrow) (c).
A significant decrease on macrophages after chemical sympathectomy was observed.