At the same time, there were significant morphological differences found after
cell transformation when the cells were observed by Giemsa staining.
Martin et al., "Spontaneous human adult stem
cell transformation," Cancer Research, vol.
Large
cell transformation was suspected, but the specimen showed a diffuse mixed cell pattern.
The separate pathological effects of high-risk HPV E6 and E7 on the cell cycle complement each other, and together E6 and E7 mediate the HPV-associated epithelial
cell transformation and promote cellular genomic instability that predisposes the infected cells to full malignant transformation.
Warnes, "Endothelial
cell transformation in primary biliary cirrhosis: a morphological and biochemical study," Hepatology, vol.
(1) The prognostic factors of MF include the type and extent of skin involvement, (2-4) the presence of extracutaneous disease, (2) advanced age, (4) male sex, (4) folliculotropic variant, (2,4) elevated lactate dehydrogenase (LDH), (4) and large
cell transformation. (4,5) In a large cohort of transformed MF patients, the extent of skin involvement and extracutaneous transformation were associated with worse disease-specific survival and overall survival.
The topics include the use of human embryonic stem cells in high-throughput toxicity assays, high-throughput screening assays to assess chemical phototoxicity, an automated soft agar colony formation assay for the high-throughput screening of malignant
cell transformation, single-cell imaging cytometry-based high-throughput analysis of drug-induced cardiotoxicity, and evaluating the peroxisomal phenotype in high content toxicity profiling.
The revolutionary biotechnology discoveries of these three individuals--each working in separate facilities on two continents--unlocked the key to plant
cell transformation using recombinant DNA.