Luminal UC was enriched with papillary morphology,
FGFR3 mutations, and erb-b2 receptor tyrosine kinase 2 (ERBB2) amplifications, and their gene expression profiles were controlled by peroxisome proliferator activator receptor [gamma] (PPAR[gamma]).
Activating mutations of
FGFR3, which have an effect on the negative regulation of cartilage growth are encountered in hypochondroplasia and achondroplasia (10).
The results confirmed that alterations involving RB1 and NFE2L2 were enriched in basal cancers, whereas alterations involving
FGFR3 and KDM6A were enriched in luminal tumors [41].
PCR amplification of exons 7,10, 13, 15 and 19 of
FGFR3 was performed.
She was admitted to the neonatal ward for investigation of a suspected dysmorphic syndrome and initial
FGFR3 molecular genetic testing for achondroplasia revealed no mutations.
The poor prognosis of patients with t(4; 14) may be in part due to its association with upregulation of the fibroblast growth factor receptor 3 (
FGFR3).
(iii) In Figure 1, "Pgfr" should be corrected to "
Fgfr3," and "Chrdl" should be corrected to "Chrdl1." The corrected figure is shown below.
When SCs robustly proliferate, the expression level of Fgf20 and
Fgfr3 decreases [67].
This translocation results in increased expression of fibroblast growth factor receptor 3 (
FGFR3) and multiple myeloma SET (MMSET) domain [11, 12].