Venereal Disease Research Laboratory (VDRL): The VDRL uses the modified
cardiolipin antigen as a target.
10N-nonyl acridine orange interacts with
cardiolipin and allows the quantification of this phospholipid in isolated mitochondria.
Cardiolipin regulates the activity of reconstituted mitochonddal caicium importer by modifying the structure of the liposome bilayer.
Gluing the respiratory chain together:
cardiolipin is required for supercomplex formation in the inner mitochondrial membrane.
ANA, anti- ds DNA antibodies, lupus anticoagulant, anti-
cardiolipin antibodiesand Coombs direct and indirect test were negative.
Results: Pretreatment of MC3T3-E1 cells with paeoniflorin prevented the MG-induced cell death and formation of intracellular reactive oxygen species,
cardiolipin peroxidation, and protein adduct in osteoblastic MC3T3-E1 cells.
Results suggest that these dietary supplements are able to increase oxidative damage in brain cortex and hippocampus (with a substantial increment of the lipoperoxides and conjugated dienes in the
cardiolipin subfraction), increase the proportion Cho/phospholipids, and consequently decrease the concentration of mGSH, decrease the membrane potential, modify the proportion of
cardiolipin and lyso-derivatives, alter inner and outer mitochondrial membrane fluidities, and increase A[beta](1-42)/(1-40) ratio.
A hypercoagulable workup (protein C, protein S, factor II mutation, antithrombin III level, lupus anticoagulant, MTHFR mutation, cryoglobulin, homocystine,
cardiolipin antibody, lipoprotein (a), beta-2 glycoprotein) showed abnormality of Factor V Leiden with heterozygousity for R506Q polymorphism.
Rheumatic heart disease patients demonstrated higher occurrence of antibodies to
cardiolipin [16, 17], however, immunoglobulin G and M antibodies to
cardiolipin increased significantly with disease activity [17].
It's a complex driven by
cardiolipin, which re-energizes the skin and boosts its natural ability to repair.
(8) This is explained by the presence of
cardiolipin (phospholipid) in the Venereal Disease Research Laboratory test reagent.