By modifying gene expression by the axolotls' microRNA, they forced the human pairing of c-Fos with
c-Jun. The salamanders with the human pairings couldn't regain a functioning spinal cord after injury, instead forming the scar tissue that occurs in human injury repair.
Among the signal transduction pathways in pituitary gonadotrophs, the PKC-MAPK pathway primarily activates
c-Jun, Elk-1, and Egr-1, and the cAMP-PKA pathway primarily activates CREB and Egr-1, while the Ca2+-mediated signaling pathway primarily activates Nur77,
c-Jun, and Egr-1 (Naor et al., 1997; Melamed et al., 2012; Thompson et al., 2013).
The results showed that the phosphorylated levels of JNK and
c-Jun were both decreased after APS treatment (P<0.05 or P< 0.01, Figure 5).
The mRNA expression of PTEN, CTNNB1, MAG, CCND1 , and
c-Jun in the Wnt signaling pathway was further detected by qrt-PCR.
Pathophysiological significance of
c-jun N-terminal kinase in acetaminophen hepatotoxicity.
Spearman correlation (r) and p-value (p) of exposure indices Cr, Ni and Mn serum levels with concentration of CC16, prolactin and corticosterone, TBARS, LDH and serum protein levels of transcription factors NF-[kappa]B and
c-JUN in controls and rats exposed to dust WD and soluble form of dust SWD.
Membranes were probed with rabbit polyclonal antibodies against phosphorylated p38 MAPK, total p38 MAPK, phosphorylated JNK and total JNK, rabbit monoclonal antibodies against phosphorylated
c-Jun and total
c-Jun, or mouse monoclonal antibody against [beta]-actin.
The
c-Jun NH2-terminal protein kinase (JNKs) is part of the mitogen-activated protein kinase (MAPK) family [1, 2] and is represented in mammals by three genes coding for three isoforms: JNK1, JNK2, and JNK3.