Similar to the previous pathways discussed above, GNAS was the only up-regulated gene (expression value 0.573); while the other genes associated with these pathways are down-regulated (ATM,
CAMK4, FNBPI, ITPR1, NAPEPLD, PIK3R1, PRKA, PRKCH, and RHOH).
Of note, also the
CAMK4 kinase, which was experimentally shown to be involved in the regulation of antibody response [10], was included in the biomarker.
Fourth, the data on genetic evaluation for hypertension, such as
CaMK4 , PLA2 , and GRKs ,[sup][5] were not available from the secondary data used for this study.
Arsenic down-regulates the expression of
Camk4, an important gene related to cerebellar LTD in mice.
Sorriento et al., "
CaMK4 gene deletion induces hypertension," Journal of the American Heart Association, vol.