(71,72) Additional studies will be necessary to understand the significance of PDCs and micropapillary architecture as possible prognostic markers independent of tumor budding.
The significance of tumor budding in colorectal carcinoma, as an independent prognostic factor for adverse clinical outcomes, has now been well established.
Tumor budding in colorectal cancer-ready for diagnostic practice?
Tumour budding: a promising parameter in colorectal cancer.
Tumor budding in colorectal carcinoma: time to take notice.
The role of tumour budding in predicting survival in patients with primary operable colorectal cancer: a systematic review.
Tumor budding as a risk factor for nodal metastasis in pT1 colorectal cancers: a meta-analysis.
Tumour Budding and Survival in Stage II Colorectal Cancer: a Systematic Review and Pooled Analysis.
Systematic review and meta-analysis of the impact of tumour budding in colorectal cancer.
Prognostic value of tumor "budding" in patients with colorectal cancer.
Intra-tumoral budding in preoperative biopsy specimens predicts lymph node and distant metastasis in patients with colorectal cancer.
Prognostic significance of tumor budding in rectal cancer biopsies before neoadjuvant therapy.