The implication of this observational-data finding is that drug holidays from a
bisphosphonate regimen "may not be appropriate for all patients," Kenneth G.
Injection (Phenergan) 10 mg intramuscularly and injection Acetaminophen 500 mg intravenous was given in case they developed shivering or body aches and pains during administration of
Bisphosphonate injection; besides
Bisphosphonate an oral dose of Calcium 1200 mg, Vit.
The study participants were placed in five groups, based on fracture type and
bisphosphonate use.
In a multivariate analysis adjusted for age, BMI, education, race, quadriceps strength, and history of knee injury,
bisphosphonate users were 41% less likely to be in the fastest bone shape-changing group and 32% less likely to be in the intermediate group, compared with the slowest-changing group.
When an insufficiency fracture is identified in a patient taking a
bisphosphonate, the medication should be discontinued and a consultation with Endocrinology should be arranged.
Eight reports of atypical ulnar fractures associated with
bisphosphonate use have been published [2].
In January 2016, a task force of the American Society for Bone and Mineral Research released guidelines on the optimal duration of
bisphosphonate therapy in patients with osteoporosis.
Regarding this pathway, it is very important to evaluate the patients dental situation and oral hygiene before and during the
bisphosphonate therapy to prevent BRONJ.
A An association has been found between
bisphosphonates and "atypical" fractures in the femur (thighbone).
KEY WORDS:
Bisphosphonate, Osteoporosis, Hip fracture.