beclin 1

An evolutionarily conserved protein involved in regulating autophagy, development, tumour suppression, vacuolar protein sorting, and required for the abcission step in cytokinesis. It may play a role in antiviral host defence. Atg6/Beclin 1 may function as a VPS and autophagy protein as part of a complex with Class-III PI3 kinase, Vps34.

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BECN1

References in periodicals archive

Normal head and neck glands showed moderate to strong beclin 1 expression (Figure 1).

Expression of beclin 1 in primary salivary adenoid cystic carcinoma and its relation to Bcl-2 and p53 and prognosis

reported that these dendrimers were very efficient to deliver siRNA to rat cortical neurons, leading to almost complete removal of the target protein Beclin 1 [43].

Dendrimers as carriers for siRNA delivery and gene silencing: a review

A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1. J Biol Chem 2009;284:21412-24.

Autophagy in 5-Fluorouracil Therapy in Gastrointestinal Cancer: Trends and Challenges

Li et al., "Beclin 1 knockdown inhibits autophagic activation and prevents secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction," Autophagy, vol.

Scutellarin attenuates hypertension-induced expression of brain toll-like receptor 4/nuclear factor kappa B

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