base deletion

removal of a NUCLEOTIDE base, a purine or a pyrimidine from the DNA structure, producing a DELETION MUTATION that can have serious consequences for the related protein. See FRAMESHIFT.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

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References in periodicals archive

The exonic single base deletion mutations in patients FA82, FA121 and FA199 all resulted in frameshift mutations.

Fanconi anaemia in black South African patients heterozygous for the FANCG c.637-643delTACCGCC founder mutation

The CF mutation is a good example of the effect of base deletion on the sequence of amino acids in the protein.

What's on the genetics test?

Insertion mutations and single base deletions were rarely observed with Cpf1, but out-of-frame mutation frequencies were comparable with SpCas9 [60].

Cellular Reprogramming, Genome Editing, and Alternative CRISPR Cas9 Technologies for Precise Gene Therapy of Duchenne Muscular Dystrophy

The frequency of base substitution and small deletions including single base deletions and deletions < 1 kb formed in fiber-treated MEF cells was only 2-fold higher than those from nontreated cases.

New insight into intrachromosomal deletions induced by chrysotile in the gpt delta transgenic mutation assay

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