Evaluation of the optimized schemes for preoperative
autologous donation in cardiac elective surgery.
Currently, EPO treatment is widely used in treating anaemia caused by renal insufficiency, chemotherapy and HIV treatment, as well as preoperative
autologous donation to avoid infection by blood-borne diseases.
* Increased incidence of adverse reactions to
autologous donation.
Autologous donation effectively decreases postoperative ABT requirements but is not without risk.
* preoperative
autologous donation for minimising perioperative allogeneic blood transfusion [10],
The advantages of preoperative
autologous donation include a decreased use of banked blood, stimulation of red blood cell production, a decrease in red blood cell loss intraoperatively (Lemos & Healy 1996, Anders et al 1996) found that preoperative donation of autologous blood is associated with a reduced incidence of postoperative deep vein thrombosis after total knee replacement.
Autologous donation is thought to be safer because of the risks associated with allogeneic blood transfusions, including transfusion-related acute lung injury which can lead to death, allergic reactions, transmission of infectious agents, and immunomodulatory effects (Moonen, Knoors, van Os, Verburg, & Pilot, 2007).
The donation is made without any restriction or direction regarding who may be the recipient of transplants of the cells derived, except in the case of
autologous donation No No 6.
Pre-operative
autologous donation of blood (PAD) for possible transfusion back to the patient (who is her/himself the donor) can be performed in the case elective surgery.
(8) The Society of Obstetricians and Gynaecologists of Canada Clinical Practice Guidelines, for example, state that "[c]ollection and long-term storage of umbilical cord blood for
autologous donation is not recommended because of the limited indications and lack of scientific evidence to support the practice." (9) The clinical utility of autologous storage is said to be limited because of the very low probability that an autologous hematopoietic stem cell transplant will be required by the individual in his/her lifetime, the uncertain shelf life of stored UCB, and the fact that autologous transplants are not recommended for inherited disorders or blood cancers.