Cerebral amyloid
angiopathy occurs when amyloid proteins build up on the walls of the brain arteries.
EXAMPLE 4, SAMPLE AUTOPSY SIGNOUT: * Frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP), Type A, with: *** Severe temporal lobe atrophy, bilateral *** Frontal lobe atrophy, mild *** Hippocampal sclerosis, bilateral, severe *** Neuronal intranuclear ("lentiform") inclusions * Alzheimer disease neuropathology changes, "high", (A2,B3,C1): *** Thal phase for amyloid plaques: 3 (A2) *** Braak and Braak neurofibrillary stage: V (B3) *** CERAD neuritic plaque score: Predominantly sparse (CI) *** No cerebral amyloid
angiopathy is identified * No Lewy body disease pathology is identified Comment: FTLD-TDP, Type A, is identified with associated severe TDP-43 proteinopathy, circumscribed atrophy of bilateral anteromedial temporal lobes and bilateral hippocampal sclerosis.
Van Helmond et al., "Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid
angiopathy," Neuropathology and Applied Neurobiology, vol.
A Cerebral amyloid
angiopathy (CAA) is characterized by the accumulation of abnormal amyloid protein deposits in the walls of the brain's blood vessels.
Microscopic analysis of the biopsied specimen showed evidence of cerebral amyloid
angiopathy (CAA).
Various clinical manifestations in patients with thrombotic micro
angiopathy. J Investig Med 2002;50(3):201-206.
The project's goal is to understand how gender and the Alzheimer's disease risk factor gene apoE4 influence the molecular processes that lead to Alzheimer's-related cerebral amyloid
angiopathy (CAA).
Approximately 80-85% are primary spontaneous ICH caused by arterial hypertension or cerebral amyloid
angiopathy. Untreated hypertension is a greater risk factor than treated hypertension and hypertensive patients who discontinue their indications have greater risk than those who continue them (Woo at al, 2004).
Cerebral amyloid
angiopathy and mechanisms of brain amyloid accumulation will be investigated by researchers from Massachusetts General Hospital, Boston.
The doctors said she suffered from amyloid
angiopathy, which means, roughly, that the rubber tubing of her cranial blood vessels had turned to glass.