A well-defined range of a drug’s serum concentration at which a desired effect occurs, below which there is little effect, and above which toxicity occurs; the window differs among patients and may be determined empirically

therapeutic window

The well-defined range of a drug's serum concentration at which a desired effect occurs, below which there is little effect, above which toxicity occurs; the TW differs among Pts and may be determined empirically. See Therapeutic drug monitoring. Cf Window.

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References in periodicals archive

Being prone for a narrow therapeutic window, small changes in warfarin concentrations for example due to codispensed drugs, may lead to an increased or decreased anticoagulation, potentially with devastating consequences.

Karolinska Institutet: Clinically important interactions associated with warfarin treatment

By rendering healthy blood and bone marrow cells 'invisible' to CD33-targeted therapies, VOR33 aims to significantly improve the therapeutic window and effectiveness of these AML therapies with potential to broaden clinical benefit to different patient populations.

Vor Biopharma Names Ang as President and Chief Executive Officer

Targeting of the inhibitor enzyme Notum may provide a new way to increase the therapeutic window and to promote recovery in societies with the aging population.

Inhibiting Signals From Neighboring Cells May Help Repair Aging Tissue

Harrison believes Sarepta has a "broad therapeutic window" and should now take majority market share.

Sarepta price target raised to $220 from $165 at Morgan Stanley

Comparative Evaluation of Therapeutic Window to Thrombolysis and Time to Pain Relief in The Study Group and the Control Group Mean [+ or -] Standard Deviation Therapeutic Window Time to Pain Relief after Subjects (Hours) STK (Hours) Study group 6.32 [+ or -] 2.23 5.90 [+ or -] 4.76 Control group 4.90 [+ or -] 1.96 5.61 [+ or -] 3.36 Table 8.

POST-THERAPY OUTCOME AND ECHOCARDIOGRAPHY ANALYSIS AT THREE WEEKS OF ELDERLY PATIENTS WITH ACUTE MYOCARDIAL INFARCTION FOLLOWING THROMBOLYSIS

Endolysin technology opens a new therapeutic window for treatment of chronic inflammatory conditions, atopic dermatitis and persistent wound infections, including those caused by MRSA.

Micreos announces EUR30m for development of endolysin technology

AAV-based gene therapy is a promising therapeutic option for treating deafness but its application is limited by a potentially narrow therapeutic window. In humans, inner ear development is completed in utero and hearing becomes possible at approximately 20 weeks of gestation.

Gene Therapy Durably Reverses Congenital Deafness in Mice

His impression was "right hemisphere cerebral infarct, likely basal ganglia location." By this time, however, the plaintiff was outside the therapeutic window for administration of tissue plasminogen activator (tPA), an anticoagulant used to treat blood clots.

Permanent injuries result from delay in diagnosing stroke

The problem, Greeno said, is that chemotherapy drugs can have a very narrow therapeutic window and often cost between $10,000 and $20,000 per month.

Forget to take your medication? A new digital pill will alert you -- and your doctor

It is clear from available clinical and preclinical evidence that moderate therapeutic hypothermia should be implemented in this therapeutic window period, before onset of secondary injury and continued until this period of secondary energy failure has resolved.

THERAPEUTIC HYPOTHERMIA (TH) IN NEONATAL HYPOXIC ISCHAEMIC ENCEPHALOPATHY (HIE)