thyroglobulin
[thi´ro-glob″u-lin] an iodine-containing glycoprotein of high molecular weight found in the colloid of the follicles of the
thyroid gland; its iodinated tyrosine moieties form the active hormones
thyroxine and
triiodothyronine.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
thy·ro·glob·u·lin
(thī'rō-glob'yū-lin), [MIM*188450] 1. A protein that contains precursors of thyroid hormone usually stored in the colloid within the thyroid follicles; biosynthesis of thyroid hormone entails iodination of the
l-tyrosyl moieties of this protein and the combination of two iodotyrosines to form thyroxine, the fully iodinated thyronine; secretion of thyroid hormone requires proteolytic degradation of thyroglobulin, with the attendant release of free hormone; a defect in thyroglobulin metabolism will lead to hypothyroidism. Synonym(s):
iodoglobulin,
thyroprotein (1)
2. A substance obtained by the fractionation of thyroid glands from the hog, Sus scrofa, containing not less than 0.7% of total iodine; used as a thyroid hormone in the treatment of hypothyroidism.
Farlex Partner Medical Dictionary © Farlex 2012
thyroglobulin
(thī′rō-glŏb′yə-lĭn)n.1. A thyroid protein that is the precursor to iodine-containing hormones and is typically present in the colloid of thyroid gland follicles.
2. A substance extracted from the thyroid glands of hogs, formerly used as a thyroid hormone supplement to treat hypothyroidism.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
thyroglobulin
A 669 kD iodine-rich glycoprotein secreted by thyroid follicular cells into thyroid colloid where it is iodinated; once resorbed by follicular cells, it is cleaved into multiple units of T3–iodothyronine and T4–thyroxine. See T3, T4, Thyroid gland.McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
thy·ro·glob·u·lin
(thī'rō-glob'yū-lin) 1. A protein that contains thyroid hormone, usually stored in the colloid within the thyroid follicles; biosynthesis of thyroid hormone entails iodination of the l-tyrosyl moieties of this protein. A defect in thyroglobulin will lead to hypothyroidism.
2. A substance obtained by the fractionation of thyroid glands from pigs, Sus scrofula, containing not less than 0.7% of total iodine; used as a thyroid hormone in the treatment of hypothyroidism.
Compare:
bioregulator Medical Dictionary for the Health Professions and Nursing © Farlex 2012
thyroglobulin
A large protein molecule, the storage form and precursor of the thyroid gland hormones.Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
thyroglobulin
a protein that contains and stores THYROXINE and triiodo-thyroxine in the THYROID GLAND.Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005