Rao and Ravishankar [13] reported that it was possible that the by-products in the spent medium could lead to unwanted
feedback inhibition towards the products of interest.
Third, in addition to the classical angiotensin II-dependent effects on natrium retention, blood pressure, induction of thirst, and others, angiotensin II also acts on the release mechanisms of renin, thereby forming a
feedback inhibition of the system (Figure 1).
If the morning cortisol is less than 5 mcg/ dL, or if there is more than a 50% decrease in the baseline morning cortisol then cortisol production is considered suppressible.(5) Pituitary Cushing's Disease is only somewhat resistant to
feedback inhibition whereas ectopic tumors producing ACTH are usually completely resistant to
feedback inhibition.
Some evidence suggests that glucocorticoids play a role in hippocampal inhibition of anticipatory responses, as lesions can block
feedback inhibition of the HPA axis by the synthetic steroid dexamethasone (Magarinos et al.